摘要
吲哚胺2, 3-双加氧酶(indoleamine 2, 3-dioxygenase, IDO)是一种重要的免疫调节酶,主要通过耗竭色氨酸(tryp-tophan, Trp)和产生多种代谢产物来调节免疫效应。近年来,对IDO免疫功能的研究大多局限在肿瘤、自身免疫性疾病等领域,而在寄生虫病中的研究相对较少,尤其是寄生虫与宿主免疫互作关系的研究。本文综述了IDO介导的免疫调节作用及其与寄生虫-宿主间关系的研究进展,旨在为抗寄生虫病免疫干预方案的研究提供思路。
Indoleamine 2,3-dioxygenase(IDO) is an important immunoregulatory enzyme,which mediates immune effects by depleting tryptophan and producing multiple metabolites.Recently,the studies on the immune function of IDO have been mostly restricted in tumors and autoimmune diseases.Nevertheless,there are few studies pertaining to the role of IDO in parasitic diseases,notably in parasite-host immune interactions.This review mainly describes IDO-mediated immunoregulatory effects and its regulation of parasite-host interactions,so as to provide insights into the development of immune intervention schemes against parasitic diseases.
作者
王莉君
马培玉
刘晖
曹建平
李华美
郑明辉
WANG Li-Jun;MA Pei-Yu;LIU Hui;CAO Jian-Ping;LI Hua-Mei;ZHENG Ming-Hui(Department of Parasitology,Zunyi Medical University,Guizhou Key Laboratory of Gene Detection and Treatment,Zunyi 563003,China;Institute of Criminal Science and Technology,Jiaozuo Municipal Public Security Bureau,Henan Province,China;National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),NHC Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,China)
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2021年第2期209-212,224,共5页
Chinese Journal of Schistosomiasis Control
基金
国家自然科学基金(81760373、31960025)
贵州省科技厅科技基金(黔科合基础[2016]1168)
遵义医科大学博士启动基金项目(F-795)
卫生部寄生虫病原与媒介生物学重点实验室开放课题(WSBKFKT-201609)。
