摘要
目的探讨儿童不完全性性早熟发生的临床相关危险因素。方法选择2017年4月至2019年12月收治不完全性性早熟女童122例,按性发育特征,分单纯乳房发育组49例、单纯外阴发育组41例和单纯早初潮组32例;同时选择同一时期体检的健康女童69例,作对照组,调查女童的人口学特征和饮食生活方式、性激素水平,采用卡方检验和二分类Logistic分析。结果单纯乳房发育组、单纯外阴发育组和单纯早初潮组在母亲初潮年龄>13岁、母亲经常接触化妆品、BMI>17 kg/m^(2)、经常高油脂食物、经常饮料快餐上均高于对照组,在母亲文化水平上,单纯乳房发育组、单纯外阴发育组和单纯早初潮组低于对照组,差异均有统计学意义(P<0.05)。在经常电子设备上,单纯外阴发育组高于单纯早初潮组、对照组,在经常反季节瓜果和蔬菜上,单纯早初潮组高于对照组、单纯乳房发育组、单纯外阴发育组,在经常各类补品上,单纯乳房发育组和单纯早初潮组高于对照组,在经常人工饲养家禽上,单纯外阴发育组高于对照组,差异均有统计学意义(P<0.05)。Logistic发现母亲初潮年龄、母亲文化水平、各类补品是单纯乳房发育患儿的低危因素,BMI、高油脂食物、饮料快餐是单纯乳房发育患儿的高危因素(P<0.05)。母亲文化水平、电子设备、高油脂食物是单纯外阴发育患儿的低危因素,母亲初潮年龄、BMI、饮料快餐是单纯外阴发育患儿的高危因素(P<0.05)。人工饲养家禽、饮料快餐是单纯早初潮患儿的低危因素,母亲初潮年龄、BMI、高油脂食物是单纯早初潮患儿的高危因素(P<0.05)。结论母亲初潮早、文化水平低、食用高脂肪食物和饮料快餐、看电子设备、BMI高,不完全性性早熟女童的发生风险越大;不同性特征发育女童的危险因素有差异,BMI、饮食习惯是患儿的共同高危因素,对上述高危因素进行干预,做到早期防治�
Objective To investigate the related risk factors of incidence of incomplete sexual precocity in children.Methods A total of 122 female chidren with incomplete sexual precocity who were diagnosed in our hospital from April 2017 to December 2019 were enrolled in the study.According to the characteristics of sexual development,who were divided into simple breast development group(n=49),simple vulva development group(n=41)and simple early menarche group(n=32),at the same time,the other 69 healthy girls were enrolled as control group.The demographic characteristics,dietary lifestyle and sex hormone levels were observed and analyzed statistically.Results The age of menarche of mothers in the three observation groups was>13 years,and BMI>17kg/m^(2),with often contacting,having high fat food and fast food,which were significantly more than those in control group,however,their education levels were significantly higher than those in control group(P<0.05).The frequency of using electronic equipment in simple vulva development group was significantly higher than that in simple early menarche group and the control groupmoreover,the frequency of eating various supplement foods in simple breast development group and simple early menarche group was significantly higher than that in control group(P<0.05).Logistic analysis showed that mother’s menarche age,education levels and various supplements were the low risk factors of the female children with simple breast development,and BMI,high fat food and beverage fast food were the high risk factors of demale children with simple breast development(P<0.05).Mother’s education level,electronic equipment use and high fat food were the low risk factors of girls with simple vulvar development,and mother’s menarche age,BMI and beverage fast food were high risk factors of girls with simple vulvar development(P<0.05).Moreover artificial hand-feeding of poultry and fast food were low-risk factors for the female children with early menarche,while mother’s age,BMI and high fat food wer
作者
王雪
刘亭亭
张立双
WANG Xue;LIU Tingting;ZHANG Lishuang(Department of Pediatrics,Jishuitan Hospital,Beijing 100096,China)
出处
《河北医药》
CAS
2021年第10期1572-1575,1580,共5页
Hebei Medical Journal
关键词
儿童
不完全性性早熟
相关危险因素
children
incomplete sexual precocity
related risk factors
