摘要
目的通过改变亚胺培南的临床输注方式以提高治疗效果并减轻胃肠道的不良反应。方法收集血液系统疾病化疗后骨髓抑制期感染患者116人随机分成试验组和对照组,分别采用不同的用药方式,试验组采用亚胺培南500 mg每8 h给药1次,静脉持续泵入2 h;对照组采用亚胺培南500 mg每8 h给药1次,常规静脉滴注30 min。观察两组在用药期间的疗效及胃肠道反应的发生情况,并将对照组发生胃肠道副反应的患者调整给药方式同试验组,观察调整后胃肠道反应有无减轻。结果两组在疗效和起效时间上均有差异,且对照组胃肠道反应发生率明显高于试验组,数据有统计学意义(P<0.05);调整输注方法为静脉持续泵入2 h后,对照组胃肠道反应阳性者症状明显改善。结论应用亚胺培南500 mg每8 h一次静脉输注时,2 h静脉持续泵入方法在治疗效果以及减少胃肠道反应方面都优于传统的30 min静滴方法,值得临床推广。
Objective To improve the therapeutic effect and reduce the adverse reactions of gastrointestinal tract by changing the clinical infusion mode of imipenem.Methods 116 patients with bone marrow suppression infection after chemotherapy for hematological diseases were randomly divided into experimental group and control group.The experimental group received imipenem 500 mg once every 8 h and continuous intravenous infusion for 2 h,while the control group received imipenem 500 mg once every 8 h and routine intravenous infusion for 30 min.The gastrointestinal reactions and curative effects of the two groups were observed during the medication period,and the patients in the control group with gastrointestinal side effects were then adjusted to that as the experimental group to observe whether the gastrointestinal reactions were relieved after the adjustment.Results There were differences in the efficacy and onset time between the two groups,and the incidence of gastrointestinal reactions in the control group was significantly higher than that in the experimental group.The data were statistically significant(P<0.05).The symptoms of gastrointestinal reactions in the control group were significantly relieved after continuous intravenous infusion for 2 h.Conclusion Imipenem administered intravenously for 500 mg once every 8 h by continuous infusion for 2 h is superior to intravenous drip for 30 min in both relieving gastrointestinal reactions and curative effects,which is worthy of clinical promotion.
作者
陈岩
李珂
CHEN Yan;LI Ke(Hematology Ward,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2021年第4期424-427,共4页
Journal of Shenyang Pharmaceutical University
关键词
亚胺培南
静脉泵入
胃肠道反应
治疗效果
imipenem
intravenous pumping
gastrointestinal reaction
treatment effect
