摘要
目的评估替加环素在恶性血液病患者化疗后粒细胞缺乏伴发热中的疗效。方法选择我院血液科2016年11月至2017年5月期间应用替加环素治疗的13例恶性血液病化疗后粒细胞缺乏伴发热的患者,分析其感染特点、疗效及不良反应。结果 13例患者中,有9例(69%)感染得到控制,4例(31%)患者无效。发生恶心呕吐不良反应2例(15%)。结论对于恶性血液病患者化疗后粒细胞缺乏伴发热,反复应用多种抗感染药物效果不佳,多重耐药菌感染几率增加的情况下,可以考虑选择替加环素治疗。
Objective To evaluate the efficacy of tigecycline in the treatment of granulocytic deficiency with fever in patients with hematological malignancies after chemotherapy.Methods Thirteen patients with malignant hematopoietic disease treated with tigecycline for granule deficiency with fever after chemotherapy in our hospital from November2016 to May 2017 were analyzed.The infection characteristics,the curative effect and adverse reactions were analyzed.Results Of the 13 patients,9 cases（69%） of infetction were effectively controlled and 4 cases（31%）were ineffective.Nausea and vomiting occurred in 2 cases（15%）.Conclusion Tigecycline treatment for patients with hematological malignancies after chemotherapy with granulocyte deficiency with fever is effective,especially when repeated use of a variety of anti-infective drugs is ineffective or the probability of multiple drug-resistant infections may increased.
作者
王慧涵
邹月娟
薛雷
廖爱军
杨威
WANG Hui-han;ZOU Yue-juan;XUE Lei;LIAO Ai-jun;YANG Wei(Department of Hematology;Department of VIP, Shengiing Hospital of China Medical University, Shenyang 110004, China)
出处
《实用药物与临床》
CAS
2018年第3期282-284,共3页
Practical Pharmacy and Clinical Remedies
关键词
恶性血液病
化疗
粒细胞缺乏伴发热
替加环素
Malignant hematologic disease
Chemotherapy
Granule deficiency with fever
Tigecycline
