摘要
目的分析腹腔镜下复位治疗对小儿肠套叠T淋巴细胞亚群、一氧化氮(NO)及丙二醛(MDA)水平的影响。方法选取2019年6月至2020年6月本院收治的105例肠套叠患儿,据手术方式的差异分为腹腔镜组(n=56,行腹腔镜下复位手术)和传统组(n=49,行传统开腹手术)。比较两组手术情况、并发症发生率及复发率,比较手术前、术后24 h后T淋巴细胞亚群、NO及MDA水平。结果两组复位成功率比较差异无统计学意义(P>0.05),腹腔镜组恢复饮食时间、住院时间较传统组短,手术时间较传统组长,差异均有统计学意义(P<0.05)。两组术前T细胞亚群各指标水平比较差异无统计学意义(P>0.05),两组术后CD4+、CD8+水平降低,CD4+/CD8+水平升高,而术后24 h腹腔镜组CD4+、CD8+水平较传统组高,CD4+/CD8+水平较传统组低,差异均有统计学意义(P<0.05)。两组术前NO、MDA水平比较差异无统计学意义(P>0.05),两组治疗后NO降低,MDA水平均升高,术后24h腔镜组NO低于传统组,MDA水平低于传统组,差异均有统计学意义(P<0.05)。腹腔镜组并发症发生率(5.36%)较传统组并发症发生率(18.37%)低,差异有统计学意义(P<0.05)。腹腔镜组与传统组复发率(3.57%vs 6.12%)比较差异无统计学意义(P>0.05)。结论腹腔镜复位手术治疗小儿肠套叠疗效确切,可减轻肠缺血再灌注损伤,有效保护肠道黏膜屏障,减轻术后应激,值得推广。
Objective To analyze the effect of laparoscopic reduction therapy on the levels of T lymphocyte subsets,nitric oxide(NO)and malondialdehyde(MDA)in children with intussusception.Method The clinical data of 105 children with intussusception admitted to our hospital from June 2019 to June2020 were retrospectively analyzed.According to the differences in surgical methods,they were divided into the laparoscopic group and the traditional group.56 cases in the laparoscopic group underwent laparoscopic reduction surgery,and 49 cases in the traditional group underwent traditional laparotomy.The operation conditions,incidence of complication,and recurrence rate between the two groups were compared,and the levels of T lymphocyte subsets,NO and MDA were compared before operation and 24 hours after the operation.Result There was no difference in the success rate of reduction between the two groups(P>0.05).The time of eating recovery and hospital stay in the laparoscopic group were shorter than those in the traditional group,and the operation time was longer than that in the traditional group.The differences were statistically significant(P<0.05).Comparison between groups:There were no differences in the levels of T cell subgroups between the two groups before operation(P>0.05).The levels of CD4+and CD8+decreased,and the level of CD4+/CD8+increased in the two groups after operation.24 hours after operation,the CD4+and CD8+levels of the laparoscopic group were higher than those of the traditional group,and the CD4+/CD8+level was lower than that of the traditional group.The differences were statistically significant(P<0.05).There were no differences in the levels of NO and MDA between the two groups before operation(P>0.05).After treatment,NO decreased and MDA level increased in the two groups.Comparison between groups:The NO of the laparoscopic group was lower than that of the traditional group 24 hours after operation,and the level of MDA was lower than that of the traditional group.The differences were statistically significa
作者
魏红
王贵波
武娜
WEI Hong;WANG Guibo;WU Na(Department of Pediatrics,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075000)
出处
《分子诊断与治疗杂志》
2021年第5期736-739,743,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省卫生健康委员会科研课题(20190815)。
