期刊文献+

地西泮联合氟桂利嗪对特发性耳鸣并发失眠症患者睡眠与生命质量的影响 被引量:1

Effects of Diazepam Combined with Flunarizine on Sleep and Life Quality in Patients with Idiopathic Tinnitus Complicated with Insomnia
下载PDF
导出
摘要 目的:探讨地西泮联合氟桂利嗪对特发性耳鸣并发失眠症患者睡眠、生命质量的影响。方法:选取2018年10月至2020年10月平度市中医医院就诊的特发性耳鸣并发失眠症患者79例作为研究对象,随机分为对照组(n=39)和观察组(n=40)。对照组给予氟桂利嗪胶囊口服,观察组在对照组基础上口服地西泮,疗程均为10 d。观察2组患者治疗后10 d时睡眠质量(PSQI)、耳鸣程度(THI)、耳鸣响度及心理适应程度、生命质量(WHOQOL-BREF)的变化,同时比较2组治疗过程中药物不良反应发生情况的差异。结果:治疗后,观察组PSQI评分、THI评分、耳鸣响度及心理适应程度评分均明显低于同一时间对照组,差异有统计学意义(P<0.05);观察组WHOQOL-BREF各维度评分明显高于同一时间对照组,差异有统计学意义(P<0.05);2组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论:地西泮联合氟桂利嗪治疗特发性耳鸣并发失眠症患者,在缓解其耳鸣的同时改善睡眠状况,提升其生命质量,为预后康复提供有利条件。 Objective:To investigate the effects of diazepam combined with flunarizine on sleep and life quality in patients with idiopathic tinnitus complicated with insomnia.Methods:A total of 79 patients with idiopathic tinnitus complicated with insomnia who were treated in our hospital between January 2018 and January 2020 were selected and randomly divided into observation group(40 cases)and control group(39 cases)according to the random number table method.Control group was given oral administration of flunarizine capsules,and observation group was given diazepam on the basis of control group,and they were treated for 10 d.The sleep quality[Pittsburgh Sleep Quality Index(PSQI)],tinnitus degree[Tinnitus Handicap Inventory(THI)],tinnitus volume and psychological adaptation degree and quality of life[World Health Organization Quality of Life(WHOQOL-BREF)]were observed in the two groups before treatment and at 10 d after treatment.The occurrence of adverse drug reactions was compared between the two groups during treatment.Results:After treatment,the PSQI score,THI score,tinnitus loudness and psychological adaptation score of the observation group were significantly lower than those of the control group at the same time,and the difference was statistically significant(P<0.05).The scores of WHOQOL-BREF in the observation group were significantly higher than those in the control group at the same time(P<0.05).There were no significant differences in the incidence rates of adverse drug reactions between the two groups(P>0.05).Conclusion:Diazepam combined with flunarizine in the treatment of patients with idiopathic tinnitus complicated with insomnia can relieve the tinnitus,improve the sleep status,enhance the quality of life,and provide favorable conditions for prognosis and rehabilitation.
作者 赵丽梅 李蕾 焦楠 ZHAO Limei;LI Lei;JIAO Nan(Department of Pharmacy,Pingdu Hospital of Traditional Chinese Medicine,Pingdu 266700,China;Department of ENT Pingdu Hospital of Traditional Chinese Medicine,Pingdu 266700,China)
出处 《世界睡眠医学杂志》 2021年第3期384-386,共3页 World Journal of Sleep Medicine
关键词 地西泮 氟桂利嗪 特发性耳鸣 失眠 Diazepam Flunarizine Idiopathic tinnitus Insomnia
  • 相关文献

参考文献8

二级参考文献67

共引文献3767

同被引文献13

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部