摘要
目的分析树突状细胞(DC)-细胞因子诱导的杀伤细胞(CIK)联合FAC化疗方案治疗乳腺癌的疗效及对患者免疫功能和肿瘤标志物水平的影响。方法选取2017年4月-2019年6月收治的78例乳腺癌患者,根据病床号分为对照组和观察组,每组39例。对照组给予FAC化疗方案治疗,观察组给予FAC联合DC-CIK化疗方案治疗。比较两组的免疫功能指标、肿瘤标志物水平、不良反应发生率、临床疗效、生活质量评分。结果治疗后,观察组免疫功能指标均显著高于对照组(均P<0.05)。与治疗前比较,对照组免疫功能指标均显著降低(均P<0.05),观察组免疫功能指标均显著升高(均P<0.05)。治疗后,两组肿瘤标志物水平比较差异均有统计学意义(均P<0.05)。与治疗前比较,两组肿瘤标志物水平均显著降低(均P<0.05)。观察组不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。对照组治疗总有效率和疾病控制率均显著低于观察组(均P<0.05)。治疗后,两组生活质量评分比较差异均有统计学意义(均P<0.05)。与治疗前比较,两组生活质量评分均显著升高(均P<0.05)。结论DC-CIK联合FAC化疗方案可有效改善乳腺癌患者的免疫功能,降低肿瘤标志物水平,安全性较高,疗效显著。
Objective To analyze the curative effect of dendritic cell(DC)-cytokine-induced killer cell(CIK)combined with FAC chemotherapy in treatment of breast cancer and the impact on immune function and levels of tumor markers.Methods Seventy-eight breast cancer patients treated in Hospital of Ninghe District from April 2017 to June 2019 were selected and divided into control group and observation group according to the number of hospital bed,39 patients in each group.The patients in control group were treated by FAC chemotherapy,the patients in observation group were treated by FAC combined with DC-CIK chemotherapy.The immune function indexes,levels of tumor markers,incidence rates of adverse reactions,clinical effects,the scores of life quality in the two groups were compared.Results After treatment,immune function indexes in observation group were statistically significantly higher than those in control group(P<0.05).Compared with before treatment,immune function indexes in control group decreased significantly(P<0.05),immune function indexes in observation group increased significantly(P<0.05).After treatment,there were statistically significant differences in the levels of tumor markers between the two groups(P<0.05).Compared with before treatment,the levels of tumor markers in the two groups decreased significantly(P<0.05).The incidence rate of adverse reactions in observation group was statistically significantly lower than that in control group(P<0.05).The total effective rate and disease control rate in control group were statistically significantly lower than those in observation group(P<0.05).After treatment,there was statistically significant difference in the score of life quality between the two groups(P<0.05).Compared with before treatment,the scores of life quality in the two groups increased significantly(P<0.05).Conclusion DC-CIK combined with FAC chemotherapy can effectively regulate immune function of breast cancer patients,reduce the levels of tumor markers,the safety is high,the curative effect is s
作者
苗培田
佟仲生
鲍双振
MIAO Pei-Tian;TONG Zhong-Sheng;BAO Shuang-Zhen(Hospital of Ninghe District,Tianjin,301500,China;不详)
出处
《中国妇幼保健》
CAS
2021年第9期2011-2015,共5页
Maternal and Child Health Care of China
基金
河北省卫生计生委医学科学研究重点课题计划项目(20181571)。
