摘要
目的观察小儿复方氨基酸联合利巴韦林治疗小儿轮状病毒性肠炎(RVE)的疗效及对心肌指标的影响。方法80例RVE患儿,采用随机数字表法分为观察组与对照组,各40例。对照组给予常规补液纠正水电解质紊乱及酸碱失衡治疗,观察组在对照组基础上加用小儿复方氨基酸联合利巴韦林治疗。比较两组临床疗效、炎性因子[超敏C反应蛋白(hs-CRP)]及心肌酶指标[磷酸肌酸激酶同工酶(CK-MB)、磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)、血清天门冬氨酸氨基转移酶(AST)]水平、不良反应发生情况。结果观察组患儿治疗总有效率为95.0%高于对照组的77.5%,差异具有统计学意义(P<0.05)。两组患儿治疗后hs-CRP、CK-MB、CK、LDH、AST水平均明显低于本组治疗前,且观察组hs-CRP(4.75±1.43)mg/dl、CK-MB(28.56±7.12)U/L、CK(142.65±19.38)U/L、LDH(220.32±23.14)U/L、AST(30.20±9.31)U/L,显著低于对照组的(8.31±1.65)mg/dl、(39.47±6.86)U/L、(176.57±20.48)U/L、(248.53±24.35)U/L、(45.15±10.44)U/L,差异具有统计学意义(P<0.05)。结论小儿复方氨基酸联合利巴韦林治疗小儿RVE的疗效显著,可有效抑制炎症反应,减轻心肌损伤。
Objective To observe the efficacy of pediatric compound amino acid combined with ribavirin in the treatment of infantile rotavirus enteritis(RVE)and its influence on myocardial indexes.Methods A total of 80 RVE children were divided into observation group and control group according to random numerical table,with 40 cases in each group.The control group was treated with conventional fluid supplementation to correct the water and electrolyte imbalance and acid-base imbalance treatment,and the observation group was treated with pediatric compound amino acid combined with ribavirin on the basis of the control group.The clinical efficacy,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP)],myocardial indexes[creatine kinase isoenzyme(CK-MB),creatine kinase(CK),lactate dehydrogenase(LDH),aspartate aminotransferase(AST)]levels and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.0%,which was higher than 77.5%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of hs-CRP,CK-MB,CK,LDH and AST of the two groups were obviously lower than those before treatment;the hs-CRP(4.75±1.43)mg/dl,CK-MB(28.56±7.12)U/L,CK(142.65±19.38)U/L,LDH(220.32±23.14)U/L and AST(30.20±9.31)U/L of the observation group were significantly lower than(8.31±1.65)mg/dl,(39.47±6.86)U/L,(176.57±20.48)U/L,(248.53±24.35)U/L and(45.15±10.44)U/L of the control group.All the difference was statistically significant(P<0.05).Conclusion Combination of pediatric compound amino acid and ribavirin shows remarkable efficacy in the treatment of rotavirus enteritis,and it can effectively inhibit inflammatory reactions and reduce myocardial injury.
作者
颜志远
YAN Zhi-yuan(Jiaoling County People’s Hospital,Meizhou 514100,China)
出处
《中国现代药物应用》
2021年第10期144-146,共3页
Chinese Journal of Modern Drug Application
关键词
小儿复发氨基酸
利巴韦林
病毒性肠炎
心肌酶谱
Pediatric compound amino acid
Ribavirin
Rotavirus enteritis
Myocardial enzymes
