摘要
目的分析海南地区汉族人群他汀类药物相关SLCO1B1和ApoE基因多态性分布特征及临床意义。方法应用聚合酶链反应(PCR)-荧光探针法检测海南地区汉族体检者SLCO1B1和ApoE基因型,统计分析其基因频率、分布特征及不同性别基因多态性分布差异。结果海南地区汉族人群SLCO1B1各基因型频率为:*1a/*1a 6.10%、*1a/*1b 28.14%、*1b/1b 41.38%、*1a/*50.70%、*1a/*154.69%、*1b/1516.10%、*5/*50.23%、*5/*150%、*15/*151.76%。ApoE各基因型频率为:e2/e21.52%、e2/e313.01%、e2/e41.41%、e3/e368.35%、e3/e415.24%、e4/e40.47%。不同性别间基因多态性的差异无统计学意义(P﹥0.05)。结论海南地区汉族人群的SLCO1B1和ApoE基因型频率与其他中国地区汉族人群报道一致,与国外其他种族报道有差异,分布存在种族差异性。临床医生应据此调整他汀类药物用药剂量和选择降脂药种类,并加强ApoE4风险类基因型人群的管理。
Objective To analyze the distribution and clinical significance of SLCO1B1 and apolipoprotein E(ApoE)gene polymorphisms related to stains in Han population in Hainan province.Methods SLCO1B1 and ApoE genotypes of Han population in Hainan were determined by polymerase chain reaction(PCR).The distribution of genotype frequency and the distribution of gene polymorphism in different gender were analyzed.Results The frequencies of SLCO1B1 genotypes were as follow:*1a/*1a 6.10%,*1a/*1b 28.14%,*1b/1b 41.38%,*1a/*50.70%,*1a/*154.69%,*1b/1516.10%,*5/*50.23%,*5/*150%,*15/*151.76%.The frequencies of ApoE genotypes were as follow:e2/e21.52%,e2/e313.01%,e2/e41.41%,e3/e368.35%,e3/e415.24%,e4/e40.47%.There was no significant difference in gene polymorphism between the male and female.Conclusion The distribution of SCLO1B1 and ApoE genotypes in Han population in Hainan is consistent with that in Han population in other region in China,but it was different from that in different races abroad.The dosage of statins and the type of lipid-lowering drugs should be adjusted according to the distribution of stains-related gene polymorphism.
作者
阮和球
陈君
夏梦娟
黄白丽
庞海云
朱娟
刘雪征
Ruan Heqiu;Chen Jun;Xia Mengjuan;Huang Baili;Pang Haiyun;Zhu Juan;Liu Xuezheng(Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311)
出处
《国际老年医学杂志》
2021年第3期143-147,176,共6页
International Journal of Geriatrics
基金
海南省科协青年科技英才学术创新计划项目(QCXN201923)。
