期刊文献+

桂枝茯苓丸对子宫肌瘤患者血清VEGF、COX-2及HIF-1α表达水平的影响 被引量:19

Effects of Guizhi Fuling Pill(桂枝茯苓丸)on Expression Levels of Serum VEGF,Cox-2 and HIF-1αin Hysteromyoma Patients
下载PDF
导出
摘要 目的分析桂枝茯苓丸对子宫肌瘤患者血清血管内皮生长因子(VEGF)、环氧合酶2(COX-2)及低氧诱导因子-1α(HIF-1α)表达水平的影响。方法选取2017年4月—2019年4月该院收治的子宫颈瘤患者196例,随机分为观察组、对照组各98例,对照组予以米非司酮治疗,观察组在此基础上应用桂枝茯苓丸治疗,比较两组临床疗效及治疗前后子宫肌瘤体积、血清性激素[卵泡刺激素(FSH)、雌激素(E2)、孕酮(P)、黄体生成素(LH)]、血液流变学指标[血浆黏度(PV)、全血黏度低切(LS)、全血黏度高切(HS)、血小板聚集率(ARBC)]、VEGF、COX-2、HIF-1α水平、不良反应发生率。结果观察组治疗有效率明显高于对照组(P<0.05);治疗1、2、3个月观察组子宫肌瘤体积小于对照组,差异有统计学意义(P<0.05);治疗后观察组E2、P、LH水平明显低于对照组(P<0.05),两组FSH水平比较差异无统计学意义(P>0.05);观察组治疗后PV、LS、HS、ARBC低于对照组(P<0.05);观察组治疗后血清VEGF、COX-2及HIF-1α水平低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论桂枝茯苓丸用于子宫肌瘤患者中,可明显提高临床疗效,改善患者子宫肌瘤体积、性激素水平、血液流变学指标,可能与下调VEGF、COX-2、HIF-1α的表达有关,且安全性可靠,值得在临床推广实践。 Objective To analyze effects of Guizhi Fuling Pill(桂枝茯苓丸)on expression levels of serum vascular endothelial growth factor(VEGF),cyclooxygenase 2(COX-2)and hypoxia-inducible factor-1α(HIF-1α)in hysteromyoma patients.Methods A total of 196 hysteromyoma patients who were admitted to the hospital from April 2017 to April 2019 were enrolled.They were randomly divided into observation group and control group,98 cases in each group.The control group was treated with mifepristone,while the observation group was additionally treated with Guizhi Fuling Pill.The clinical curative effect,hysteromyoma volume,levels of serum sex hormones[follicle stimulating hormone(FSH),estrogen(E2),progesterone(P),luteinizing hormone(LH)],hemorheology indexes[plasma viscosity(PV),whole blood low-cutviscosity(LS),whole blood high-cut viscosity(HS),platelet aggregation rate(ARBC)],VEGF,COX-2 and HIF-1αbefore and after treatmentand the incidence of adverse reactions were compared between the two groups.Results The response rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After 1,2 and 3 months of treatment,the hysteromyoma volumein the observation group was smaller than that in the control group(P<0.05).After treatment,levels of E2,P and LH in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in FSH level between the two groups(P>0.05).After treatment,levels of PV,LS,HS and ARBC in the observation group were lower than those inthe control group(P<0.05).After treatment,levels of serum VEGF,COX-2 and HIF-1αin the observation group were lower than those in the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of Guizhi Fuling Pill in hysteromyoma patients can significantly improve clinical curative effect,improve hysteromyoma volume,levels of sex hormones and hemorheology indexes,which may be related to dow
作者 杨真 尚玉敏 程凤 YANG Zhen;SHANG Yumin;CHENG Feng(Department of Obstetrics and Gynecology,Tianjin Hospital,Tianjin 300211,China)
出处 《辽宁中医杂志》 CAS 2021年第3期95-98,共4页 Liaoning Journal of Traditional Chinese Medicine
关键词 桂枝茯苓丸 子宫肌瘤 VEGF COX-2 HIF-1Α Guizhi Fuling Pill(桂枝茯苓丸) hysteromyoma VEGF COX-2 HlF-1α
  • 相关文献

参考文献18

二级参考文献245

共引文献699

同被引文献355

引证文献19

二级引证文献73

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部