摘要
制备侧柏叶、何首乌复合提取物,采用体外1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除率实验、5α-还原酶抑制实验和小鼠动物模型对其进行防脱发功效研究。结果表明,该复合提取物在100 mg/mL的有效浓度下可有效清除DPPH,体外可显著抑制5α-还原酶活性,动物试验结果表明能明显改善小鼠雄激素源性脱发。该复合提取物具有防脱发功效,可用于防脱发个人护理用品的开发。
The compound extract of Platycladus orientalis and Polygonum multiflorum was prepared,and the anti-hair loss effects were studied by 1,1-Diphenyl-2-picrylhydrazylradical2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl(DPPH)clearance test in vitro,5α-reductase inhibition test in vitro and mice experimental model.The results showed that the composite extract could effectively eliminate DPPH,and significantly inhibit 5α-reductase activity at an effective concentration of 100 mg/mL in vitro.The animal experiment result showed that it could significantly improve androgen-induced alopecia in mice.The compound extract has anti-hair loss effect and can be used in the development of anti-hair loss personal care products.
作者
马世宏
单承莺
聂韡
束成杰
Ma Shihong;Shan Chengying;Nie Wei;Shu Chengjie(Nanjing Institute of Comprehensive Utilization of Wild Plants, Nanjing 211110,China)
出处
《中国野生植物资源》
CSCD
2021年第5期43-47,共5页
Chinese Wild Plant Resources
关键词
侧柏叶
何首乌
5Α-还原酶
雄激素源性脱发
Platycladus orientalis
Polygonum multiflorum
5α-reductase
Androgen-induced Alopecia
