摘要
氧化苦参碱具有抗胃溃疡的作用,其抗胃溃疡的机制可能与其抑制胃酸分泌和中枢神经的作用有关。氧化苦参碱对肠黏膜具有保护和修复作用,可防治溃疡性结肠炎,其作用机制与其抗氧化、抗炎和免疫调节作用有关。氧化苦参碱还具有抗病毒和保护肺功能的作用。综述氧化苦参碱对胃溃疡和溃疡性结肠炎的临床药理作用的文献,并对其研究进展做了分析。
ABSTRCT Oxymatrine has the effect against gastric ulcer,its mechanism is related to inhibiting gastric acid secretion and central suppression. Oxymatrine has protection and reparation of intestinal mucosa,and effects of prevention and treatment for ulcerative colitis,whose mechanism is related to antioxidation,anti-inflammation and immunoregulation. Oxidative matrine also has antiviral and protective effects on lung function. The literatures on the clinical pharmacological effects of oxymatrine in gastric ulcer and ulcerative colitis have been reviewed,and its research progress is analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2021年第3期307-312,共6页
Anti-infection Pharmacy
