摘要
肝细胞癌(HCC)是常见的消化道恶性肿瘤,肿瘤标志物对于HCC的早期诊断及治疗预后的判断具有重要意义。异常凝血酶原(PIVKA-Ⅱ)由于其在诊断HCC方面的高特异性和敏感性,以及对肝癌细胞增殖、侵袭和转移的影响,近年来开始被用于HCC的早期诊断和治疗的监测及预后判断。本文综述近年PIVKA-Ⅱ生物学机制及其用于HCC诊断及预后判断方面的研究进展。
Hepatocellular carcinoma is a common malignancy of digestive system.Tumor markers are important for the early diagnosis and prognosis of hepatocellular carcinoma.Protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ)is of high specificity and sensitivity in hepatocellular carcinoma diagnosis.In addition,previous studies suggested that PIVKA-Ⅱplayed a role in proliferation,invasion and metastasis of hepatocellular carcinoma and could be used for prognosis of hepatocellular carcinoma.This article reviewed the recent advances in the underlying biological mechanism of PIVKA-Ⅱin hepatocellular carcinoma and concluded the value of PIVKA-Ⅱin hepatocellular carcinoma diagnosis and prognosis.
作者
马浙平
单钰莹
周叶明
陆才德
Ma Zheping;Shan Yuying;Zhou Yeming;Lu Caide(Department of Hepatopancreatobiliary Surgery,the Affiliated Lihuili Hospital,Ningbo University,Ningbo 315000,Zhejiang Province,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2021年第4期309-313,共5页
Chinese Journal of Hepatobiliary Surgery
基金
宁波市科技创新团队(2013B82010)
宁波市医疗卫生品牌学科建设项目(PPXK2018-03)。
关键词
癌
肝细胞
肿瘤标志物
异常凝血酶原
诊断
预后
Carcinoma,hepatocellular
Tumor markers
Protein induced by vitamin K absence or antagonist-Ⅱ
Diagnosis
Prognosis
