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玉屏风散联合半夏泻心汤加减治疗虚实夹杂型复发性口腔溃疡的临床疗效观察 被引量:11

Clinical Observation of Yupingfeng Powder Combined with Banxia Xiexin Decoction in Treating Recurrent Oral Ulcer
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摘要 目的研究玉屏风散联合半夏泻心汤加减治疗虚实夹杂型复发性口腔溃疡的临床疗效。方法选取2018年10月—2019年10月期间上海交通大学医学院附属瑞金医院收治的80例虚实夹杂型复发性口腔溃疡患者作为研究对象,运用随机数字表法将患者分为对照组和治疗组各40例,对照组患者采用口服维生素B2和维生素C以及康复新液治疗,治疗组患者在对照组治疗基础上同时口服玉屏风散联合半夏泻心汤加减进行治疗,疗程4周。治疗完成后,对两组患者的治疗效果进行对比,包括对比临床总疗效、血清相关指标比较,口腔溃疡最大直径及疼痛评分比较,对比治疗结束6个月后复发率。结果治疗后治疗组的临床总有效率92.5%(37/40)显著高于对照组75.0%(30/40),差异有统计学意义(P<0.05)。治疗后两组患者TNF-α血清水平较治疗前显著降低(P<0.05),且治疗组治疗后TNF-α血清水平显著低于对照组(P<0.05)。治疗后两组患者的溃疡最大直径、NRS评分较治疗前显著减小和降低(P<0.05),且治疗组治疗后溃疡最大直径、NRS评分较对照组显著减小和降低(P<0.05)。治疗结束6个月后,治疗组复发率12.5%(5/40)明显低于对照组35.0%(14/40)(P<0.05)。结论玉屏风散联合半夏泻心汤治疗虚实夹杂型复发性口腔溃疡是通过补中益气,寒热平调实现的,其起效的药理机制包括调节免疫力、抗炎、抗病毒、抗氧化、止痛、促进黏膜修复等。本研究结果显示无论是在临床疗效还是在防止病情的复发方面,中西结合治疗都体现出了明显的优势,玉屏风散联合半夏泻心汤在虚实夹杂型复发性口腔溃疡治疗中的价值值得进一步研究和推广。 Objective To study the clinical efficacy of Yupingfeng Powder combined with Banxia Xiexin Decoction in the treatment of recurrent aphthous ulcer.Methods From October 2018 to October 2019,80 patients with recurrent oral ulcers of asthenia-excess type mixed in Ruijin Hospital,Shanghai Jiaotong University School of Medicine were selected as the research objects,and the patients were divided into control group and treatment group by random number table method.There were 40 cases in each group.Patients in the control group were treated with oral vitamin B2 and vitamin C and Kangfuxin liquid.Patients in the treatment group were treated with Yupingfeng Powder combined with Banxia Xiexin Decoction on the basis of the treatment of the control group.The course of treatment was 4 weeks.After the treatment was completed,the treatment effects of the two groups of patients were compared,including the comparison of the total clinical efficacy,the comparison of serum related indicators,the comparison of the maximum diameter of the oral ulcer and the pain score,and the comparison of the recurrence rate within 6 months.Results After treatment,the total clinical effective rate of the treatment group was 92.5%(37/40) significantly higher than that of the control group 75.0%(30/40),and the difference was statistically significant(P <0.05).After treatment,the serum levels of TNF-α in the two groups were significantly lower than those before treatment(P <0.05),and the serum levels of TNF-α in the treatment group were significantly lower than those in the control group(P <0.05).After treatment,the maximum diameter of the ulcer and the NRS score of the two groups of patients were significantly reduced and lower than that before the treatment(P <0.05),and the maximum diameter of the ulcer and the NRS score of the treatment group after treatment were significantly reduced and lower than that of the control group(P <0.05).Six months after the end of treatment,the recurrence rate of the treatment group was 12.5%(5/40),which was significant
作者 陆聆韵 沈小珩 LU Ling-yun;SHEN Xiao-yu(Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025)
出处 《世界中西医结合杂志》 2021年第3期540-544,共5页 World Journal of Integrated Traditional and Western Medicine
基金 上海市卫生和计划生育委员会中医药科研基金项目(2014LQ012A)。
关键词 玉屏风散联合半夏泻心汤 复发性口腔溃疡 中西结合 补中益气 寒热平调 Yupingfeng Powder Combined with Banxia Xiexin Decoction Recurrent Aphthous Ulcer Combination of Chinese and Western Medicine Invigorating Spleen-Stomach and Replenishing Qi Mildly Regulating Cold and Heat
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