摘要
目的研究鲜竹沥正丁醇部位的化学成分。方法运用正相和反相硅胶、凝胶以及制备液相色谱方法进行分离纯化,并根据理化性质、波谱数据鉴定化合物的结构。结果从鲜竹沥正丁醇部位分离得到16个化合物,分别鉴定为sachaliside 1(1)、(Z)-4-hydroxycinnamylalcohol4-O-β-D-glucopyranoside(2)、β-hydroxypropiovanillone-3-O-β-D-glucopyranoside(3)、dihydro-p-coumaryl alcohol γ-O-glucoside(4)、(+)-南烛木树脂酚-3α-O-β-D-吡喃葡萄糖苷(5)、tortoside B(6)、丁香脂素-4-O-β-D-葡萄糖苷(7)、5,5′-二甲氧基落叶松树脂醇-4′-O-β-D-吡喃葡萄糖苷(8)、2,4,6-三甲氧基苯酚-1-O-β-D-吡喃葡萄糖(9)、苯甲醇-β-D-葡萄糖苷(10)、(1′R)-1′-(4-羟基-3,5-二甲氧基苯基)-1-丙醇-4-O-β-D-葡萄糖苷(11)、erythro-2,3-bis (4-hydroxy-3-methoxyphenyl)-3-butoxypropan1-1-ol(12)、threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxypropan1-1-ol(13)、丁香脂素(14)、lirioresinol-A(15)、(E)-p-coumaryl alcoholγ-O-methyl ether(16)。结论其中化合物2~4、6、10~13、15、16为首次从鲜竹沥中分离得到,并通过二维核磁谱补充了化合物4的碳谱数据。
Objective To study the n-butanol-soluble chemical constituents of Xianzhuli. Methods The chemical constituents were isolated by column chromatography on silica gel, ODS, Sephadex LH-20 and MPLC. Their chemical structures were elucidated on the basis of physical and chemical properties and spectral data. Results Sixteen compounds were isolated and identified as schaliside 1(1),(Z)-4-hydroxycinnamyl alcohol 4-O-β-D-glucopyranoside(2), β-hydroxypropiovanillone-3-O-β-D-glucopyranoside(3), dihydro-p-coumaryl alcohol γ-O-glucoside(4),(+)-lyonirenisol-3α-O-β-D-glucopyranoside(5), tortoside B(6), syringaresinol 4-O-β-D-glucoside(7), 5,5′-dimethoxylariciresinol 4′-O-β-D-glucopyranoside(8), 2,4,6-trimethoxyphenol-1-O-β-Dglucopyranoside(9), benzylalcohol-β-D-glucopyranoside(10),(1′R)-1′-(4-hydroxy-3,5-dimethoxylphenyl) propan-1′-ol-4-O-β-D-glucopyranoside(11), erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxypropan1-1-ol(12), threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-butoxypropan1-1-ol(13), syringarenol(14), lirioresinol-A(15), and(E)-p-coumaryl alcohol γ-O-methyl ether(16). Conclusion Compounds 2—4, 6, 10—13, 15—16 are isolated from Xianzhuli for the first time. And the carbon spectrum data of compound 4 was supplemented.
作者
赵青群
付辉政
林凯鹏
周志强
王兰欣
陈丽楠
罗跃华
ZHAO Qing-qun;FU Hui-zheng;LIN Kai-peng;ZHOU Zhi-qiang;WANG Lan-xin;CHEN Li-nan;LUO Yue-hua(School of Pharmacy,Nanchang University,Nanchang 330006,China;Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第7期1891-1897,共7页
Chinese Traditional and Herbal Drugs
基金
江西省重点研发计划一般项目(20171BBG70103)。
