摘要
目的探讨帕金森病(Parkinson’s disease,PD)患者脑电图改变及其与睡眠结构的相关性。方法回顾分析本院2017年6月-2020年6月收治的帕金森病患者126例为研究对象,根据是否合并睡眠障碍将其分为观察组(n=64)和对照组(n=62),比较2组患者脑电图异常情况、脑电图α波特点、睡眠参数各项指标、脑电图快波(β波)与慢波(θ、δ波)出现情况并分析脑电图改变与睡眠参数的相关性。结果观察组脑电图正常的比例低于对照组,而轻度异常、中度异常及重度异常的比例均高于对照组(P<0.05);2组脑电图中低波幅、频率8~9 c/s、脑波指数<25%及泛化比较均有明显差异(P<0.05);2组总睡眠时间、睡眠效率、快速眼动睡眠潜伏期、非快速眼动睡眠潜伏期1期、非快速眼动睡眠潜伏期2期、非快速眼动睡眠潜伏期3和4期、觉醒次数、欧洲神经功能缺损度(European stroke scale,ESS)评分及氧减指数比较均有明显差异(P<0.05);观察组脑电图β波、θ波、δ波均高于对照组(P<0.05);经Person相关性分析显示,脑电图β波、θ波、δ波与总睡眠时间、睡眠效率、睡眠潜伏期、快速眼动睡眠潜伏期、非快速眼动睡眠潜伏期2期、非快速眼动睡眠潜伏期3和4期呈负相关(-0.930<r<-0.130,P<0.05),而与非快速眼动睡眠潜伏期1期、觉醒次数、ESS评分、氧减指数呈正相关(0.230<r<-0.690,P<0.05)。结论PD合并睡眠障碍患者脑电波呈现不同活动情况,其睡眠障碍与脑电图活动存在一定关系,临床上可通过脑电图来判断PD患者的睡眠障碍严重程度等。
Objective To investigate the relationship between electroencephalogram(EEG) and sleep structure in patients with Parkinson’s disease(PD). Methods In this retrospective study, we enrolled 126 PD patients who were hospitalized between June 2017 and June 2020. The patients were divided into the sleep disorder group(n=64) and control group(n=62). We recorded the sleep parameters and EEG characterizes and analyzed the relationship between them.Results More patients with sleep disorders showed abnormal EEG than those without sleep disorders(P<0.05). The amplitude and frequency of EEG waves were different between the two groups(P<0.05). The total sleep time, sleep efficiency, the latency of rapid-eye-movement(REM), the latency of non-REM, number of awakening, and oxygen reduction index were also different between the two groups. The β, θ, and δ waves were higher in patients with sleep disorders(P<0.05). Furthermore, Pearson correlation analysis found that the amplitude of β, θ, and δ waves were negatively correlated with the total sleep time, sleep efficacy, sleep latency, and non-REM sleep latency periods 2, 3, and 4, while positively correlated with non-REM sleep latency period 1, the number of awakenings, ESS score, and oxygen reduction index.Conclusion EEG abnormalities are frequently found among PD patients with sleep disorders. The EEG abnormities are associated with the extent of sleep disorders. Thus, EEG can be used to predict sleep disorders in PD patients.
作者
杨渌
杨加亮
廖红霞
Yang Lu;Yang Jialiang;Liao Hongxia(Department of Neurology,Panzhihua Central Hospital,Panzhihua Sichuan 617000)
出处
《卒中与神经疾病》
2021年第2期176-179,共4页
Stroke and Nervous Diseases
关键词
帕金森病
脑电图
睡眠结构
相关性
Parkinson’s disease
Electroencephalogram(EEG)
Sleep structure
Correlation
