摘要
急性缺血性脑卒中已成为导致人类尤其是高龄患者死亡和致残的重要原因之一,阿替普酶静脉溶栓是其重要治疗方式,但高龄患者基础疾病多、整体状况差等增加了颅内出血转化发生的风险。颅内出血转化使患者病情恶化,是阿替普酶静脉溶栓最严重的并发症,也是高龄患者阿替普酶静脉溶栓治疗率低的重要原因之一,所以需要高度关注高龄患者阿替普酶静脉溶栓后颅内出血转化的发生机制及其危险因素以降低颅内出血转化发生风险,改善预后,降低致残率及致死率。
Acute ischemic stroke has become one of the important causes of death and disability in human beings,especially in elderly patients.Intravenous thrombolysis with alteplase is an important treatment.However,there are many underlying diseases and poor overall conditions in elderly patients,which increase the risk of intracranial hemorrhage.Intracranial hemorrhage transformation makes the patient′s condition worse,which is the most serious complication of alteplase intravenous thrombolysis,and also one of the important reasons for the low treatment rate of alteplase intravenous thrombolysis in elderly patients.Therefore,we need to pay close attention to the occurrence mechanism and risk factors of intracranial hemorrhage transformation after alteplase intravenous thrombolysis in elderly patients,so as to reduce the risk of intracranial hemorrhage transformation,improve the prognosis and reduce the risk of morbidity and mortality.
作者
吕洋
高思山
滕继军
Lyu Yang;Gao Sishan;Teng Jijun(Medical Department of Qingdao University,Qingdao 266071,China;Department of Neurology,Qingdao Huangdao District Hospital of Traditional Chinese Medicine,Qingdao 266500,China;Department of Neurology,the Affiliated Hospital of Qingdao University,Qingdao 266555,China)
出处
《中国医师杂志》
CAS
2021年第4期637-640,F0003,共5页
Journal of Chinese Physician
