摘要
目的探讨鼻内镜手术联合糖皮质激素治疗鼻息肉患者的临床效果。方法选取江西省南昌市第三医院和南昌大学第一附属医院2018年1月~2019年8月接诊的82例鼻息肉患者为研究对象,按照随机数字表法分为联合组(41例)和对照组(41例)。对照组采用鼻内镜手术治疗,联合组在对照组的基础上加用糖皮质激素治疗。比较两组的围术期指标、临床疗效、炎症因子及复发情况。结果联合组的术中失血量少于对照组,住院时间、手术操作时间短于对照组,治疗总有效率高于对照组,差异有统计学意义(P<0.05);联合组术后6个月的IL-17、IL-5水平为(2.65±1.05)μg/L、(152.64±21.65)ng/L,低于对照组的(3.35±1.21)μg/L、(182.21±25.21)ng/L,差异有统计学意义(P<0.05);联合组的复发率为4.88%,低于对照组的24.39%,差异有统计学意义(P<0.05)。结论鼻内镜手术联合糖皮质激素治疗鼻息肉患者能够提高治疗效果,减少失血量,缩短手术用时及住院时间,降低炎症因子水平与复发率。
Objective To investigate the clinical effect of nasal endoscopic surgery combined with glucocorticoids in the treatment of patients with nasal polyps.Methods A total of 82 patients with nasal polyps admitted to the Third Hospital of Nanchang City in Jiangxi Province and the First Affiliated Hospital of Nanchang University from January 2018 to August 2019 were selected as study subjects.According to the random number table method,they were divided into the combined group(41 cases)and the control group(41 cases).The control group was treated with nasal endoscopic surgery,and the combined group was treated with glucocorticoid on the basis of the control group.Perioperative indicators,clinical efficacy,inflammatory factors and recurrence were compared between the two groups.Results Intraoperative blood loss in the combined group was less than that in the control group,the length of hospital stay and operation time in the combined group were shorter than those in the control group,and the total effective rate of treatment in the combined group was higher than that in the control group,with statistically significant differences(P<0.05).The levels of IL-17 and IL-5 in the combined group at 6 months after surgery were(2.65±1.05)g/L and(152.64±21.65)ng/L,which were lower than those in the control group([3.35±1.21]g/L and [182.21±25.21]ng/L),with statistically significant differences(P<0.05).The recurrence rate of the combined group was 4.88%,which was lower than that of the control group(24.39%),and the difference was statistically significant(P<0.05).Conclusion Nasal endoscopic surgery combined with glucocorticoid in the treatment of nasal polyps can improve the treatment effect,reduce blood loss,shorten the operation time and hospital stay,reduce the level of inflammatory factors and the recurrence rate.
作者
刘云香
黄敏
张志远
LIU Yun-xiang;HUANG Min;ZHANG Zhi-yuan(Department of Otorhinolaryngology,the Third Hospital of Nanchang City,Jiangxi Province,Nanchang330000,China;Department of Otorhinolaryngology,the First Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang330000,China)
出处
《中国当代医药》
CAS
2021年第14期141-143,共3页
China Modern Medicine
关键词
鼻息肉
糖皮质激素
鼻内镜手术
炎症因子
复发
Nasal polyps
Glucocorticoids
Nasal endoscopic surgery
Inflammatory factors
Recurrence