摘要
目的了解新型冠状病毒(SARS-CoV-2)IgG抗体阳性患者的血常规及肾功能参数特点,鉴别诊断SARS-CoV-2感染患者及抗体阳性患者的血液指标,为早期临床诊断提供依据。方法回顾性分析常州市第一人民医院2020年3月19-31日门诊检测SARS-CoV-2 IgG和IgM抗体阳性患者,体检中心健康成年人及传染病院核酸阳性确诊的SARS-CoV-2感染患者临床资料。所有患者均检测血常规、肾功能,以及影像学CT平扫胸部检查,选择有鉴别意义的标志物。结果新型冠状病毒肺炎患者白细胞计数、淋巴细胞计数及嗜酸性粒细胞计数均明显低于健康成年人,差异均有统计学意义(P<0.05);肾功能参数中,新型冠状病毒肺炎患者的肌酐明显高于健康成年人,差异有统计学意义(P<0.05)。SARS-CoV-2 IgM和IgG抗体阳性患者与健康成年人比较,白细胞计数差异无统计学意义(P>0.05);但淋巴细胞计数明显低于健康成年人,差异有统计学意义(P<0.05);肾功能参数中,两组肌酐水平比较,差异无统计学学意义(P>0.05)。结论 SARS-CoV-2 IgM和IgG抗体阳性提示为感染中后期或既往感染,抗体阳性核酸检测阴性是否为假阳性或无症状感染者自愈值得临床进一步观察研究。血常规及肾功能参数在鉴别诊断中存在一定意义,可为核酸及CT诊断提供补充。
Objective To understand the characteristics of blood routine and renal function parameters in patients with SARS-CoV-2 IgG antibody positive,and to identify the blood indexes of patients with SARS-CoV-2 infection and antibody positive patients,so as to provide evidence for early clinical diagnosis.Methods A retrospective analysis was performed on the clinical data of SARS-CoV-2 IgM and IgG antibody positive patients who visited the First People′s Hospital of Changzhou from March 19,2020 to March 31,2020,healthy adults in physical examination center and SARS-CoV-2 infected patients confirmed by nucleic acid infection in infectious disease hospital.Patients were screened for blood routine,renal function and CT,markers with identification significance were selected.Results The white blood cells,lymphocyte count and eosinophils leukocytes of COVID-19 patients were significantly lower than healthy adults,and differences were statistically significant(P<0.05).In the parameters of renal function,the creatinine parameter of COVID-19 patients were significantly higher than that of the healthy adults,and the difference was statistically significant(P<0.05).The results showed that white blood cells was no significant difference between SARS-CoV-2 antibody positive patients and the healthy adults(P>0.05),but the lymphocyte count of COVID-19 patients was significantly lower than that of the healthy adults,and the difference was statistically significant(P<0.05).There was no significant difference between the two groups in the creatinine parameter(P>0.05).Conclusion SARS-CoV-2 IgM and IgG antibody positive indicates the middle and late stage of infection or previous infection.Whether antibody positive and nucleic acid negative is false positive or asymptomatic infection is worth further clinical observation and study.Blood routine and renal function parameters have certain significance in differential diagnosis,and can be used as a supplement for nucleic acid and CT diagnosis.
作者
季云
巢蓓
郑国军
周萃星
薛冬
陆皓
JI Yun;CHAO Bei;ZHENG Guojun;ZHOU Cuixing;XUE Dong;LU Hao(Department of Clinical Laboratory,the First People′s Hospital of Changzhou,Changzhou,Jiangsu 213003,China;Department of Clinical Laboratory,the Third People′s Hospital of Changzhou,Changzhou,Jiangsu 213001,China;Department of Urology,the First People′s Hospital of Changzhou,Changzhou,Jiangsu 213003,China)
出处
《检验医学与临床》
CAS
2021年第10期1390-1392,1397,共4页
Laboratory Medicine and Clinic
