摘要
特发性肺纤维化(IPF)是一种常见的,以气道重塑、炎症、肺泡破坏和纤维化为特征的致死性间质性肺病。哺乳动物雷帕霉素靶蛋白复合物1/4E结合蛋白1(mTORC1/4E-BP1)轴与成纤维细胞表达胶原关系密切,其在肺纤维化中的作用尚待进一步阐明。中医药在改善IPF患者肺功能、运动能力和生活质量等方面都有着良好的疗效。中医"异病同治"为柴胡治疗肺纤维化提供了中医理论依据,而西医研究已初步表明柴胡复方、单药及有效成分均对肺纤维化有良好的治疗效果。因此,本文将阐述mTORC1/4E-BP1轴在IPF病理机制中的作用,以及柴胡有效成分对于磷酸肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/mTOR通路的研究结果,为IPF的治疗及药物研发提供参考依据。
Idiopathic pulmonary fibrosis(IPF) is a common, lethal interstitial lung disease characterized by airway remodeling,inflammation,alveolar destruction,and fibrosis. The mammalian target of rapamycin complex 1/4 E binding protein 1(mTORC1/4 E-BP1)axis is closely related to the expression of collagen by fibroblasts,and its role in pulmonary fibrosis remains to be further elucidated. Traditional Chinese medicine(TCM)has shown promising efficacy in improving the lung function,exercise capacity,and quality of life in patients with IPF. The theory of "same treatment for different diseases" provides a TCM theoretical basis for the treatment of pulmonary fibrosis with Bupleuri Radix,while the research in western medicine has preliminarily shown that both the formulation and single herb as well as the active ingredients of Bupleuri Radix have good therapeutic effects on pulmonary fibrosis. Therefore,this review will elaborate on the role of the mTORC1/4 E-BP1 axis in the pathomechanism of IPF,as well as the research results of the active components of Bupleuri Radix on the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin protein(PI3 K/AKT/mTOR)pathway,so as to provide a reference for the treatment and drug development of IPF.
作者
沈枭
何凌林
范伏元
柳玉佳
欧慧萍
肖雪飞
李妲
SHEN Xiao;HE Ling-lin;FAN Fu-yuan;LIU Yu-jia;OU Hui-ping;XIAO Xue-fei;LI Da(Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Hunan Traditional Chinese Medical College,Zhuzhou 412012,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第10期239-250,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省自然科学基金项目(2020JJ5434)
湖南省教育厅科学研究项目(19C1446)
湖南省教育厅科学研究项目(20B442)
湖南省中医药科研计划项目(2021165)。
