摘要
目的采用数据挖掘探讨中医药治疗年龄相关性黄斑变性的用药规律。方法检索中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据知识服务平台(Wanfang)、维普中文期刊(VIP)、Medline等数据库中中医药治疗年龄相关性黄斑变性的有关文献,统计药物的使用频次、功效类别、性味归经,并进行关联规则和聚类分析。结果经过筛选后,共纳入处方106首,中药165味。中药使用频次较高的有茯苓、枸杞子、当归、川芎、白术等。药物功效以补虚药、清热药及止血药为主;药性多用温,药味以甘苦为主;药物归经使用频次较高的为肝经、肾经和脾经;常用药对组合为"茯苓-白术",核心组合为"菟丝子-熟地黄-枸杞子-车前子"。并最终根据组方规律演化得到5个治疗年龄相关性黄斑变性的新处方,其功效有健脾利水渗湿、补脾益肾、填精明目、行气补血活血、凉血化瘀止血、消痞散结止血等。结论治疗年龄相关性黄斑变性的中药复方中以补虚药多见,与"健脾益气补血,滋养肝肾"的基本治则相一致。"茯苓-白术","菟丝子-熟地黄-枸杞子-车前子"等配伍在治疗老年性黄斑变性中最常用。在治疗上以健脾益气、益肾填精明目、补血活血、凉血化瘀止血、消痞散结止血等为主要治法。
Objective Data mining was used to discover the medication rules of traditional Chinese medicine in the treatment of age-related macular degeneration. Methods We performed searches on the Chinese biomedical literature database,CNKI,Wanfang,VIP,Medline,and other databases related to the treatment of age-related macular degeneration with traditional Chinese medicine,and made statistics on the frequency of drug use,efficacy category, flavor and meridian tropism. Similarly, correlation Rules and cluster analysis are carried out. Results After screening,a total of 106 prescriptions and 165 traditional Chinese medicines were included in the study. Poria cocos,Wolfberry,Angelica sinensis,Ligusticum chuanxiong,Atractylodes macrocephala koidz,etc,were used frequently. The efficacy of the drugs were mainly tonic drugs, heat-clearing drugs and hemostatic drugs. The medicinal properties are mostly warm,and the taste of the drug is mainly sweet and bitter;The liver meridian,kidney meridian,and spleen meridian were frequently used. The common compatibility of drug pairs is"Poria cocos-Atractylodes macrocephala Koidz",and the core combination is "Cuscuta chinensis-Rehmannia glutinosa-Lyciumbarbarum-Plantain Seed". According to the rules of formulas,five new prescriptions for the treatment of age-relatedmacular degeneration have been obtained. The effects are respectively invigorating the spleen and diuresis,invigorating the spleen and kidney,filling the eyesight,promoting qi and blood circulation,cooling and removing blood stasis and stopping bleeding,eliminating ruffian and dispersing knot,hemostasis,etc. Conclusion Tonic drugs are widely used in traditional Chinese medicines for the treatment of age-related macular degeneration,which are consistent with the basic treatment of "invigorating the spleen,nourishing qi and blood,and nourishing the liver and kidney". Poria cocos-Atractylodes macrocephala Koidz and Cuscuta chinensis-Rehmannia glutinosa-Lycium chinense-Plantain Seed are the most common compatibility in the treatment o
作者
王燕
周冰倩
庞龙
袁远
李坚昊
WANG Yan;ZHOU Bingqian;PANG Long;YUAN Yuan;LI Jianhao(Department of Ophthalmology,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第4期579-584,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(81503618)
广东省科技计划项目(2017ZC0176)
广东省中医院中医药科学技术研究专项(YN2018M703)。
关键词
年龄相关性黄斑变性
数据挖掘
中药
用药规律
聚类分析
Age-related macular degeneration
data mining
traditional Chinese medicine
medication rule
cluster analysis
