摘要
目的:观察分析四藤方加减联合化疗对胃癌术后无进展生存期的影响。方法:选取本院2018年10月~2020年7月收治的80例需行胃癌手术治疗的患者作为研究对象,通过数字奇偶法分为对照组(n=40)和治疗组(n=40),对照组患者予以单纯化疗进行治疗,治疗组患者在对照组基础上加以四藤方加减药物进行治疗,两组患者均在治疗4个周期后观察比较其中医症候积分、不良反应发生率、临床疗效、生活质量以及无进展生存时间。结果:中医症候积分对比,治疗组患者治疗后中医症候积分较对照组下降更显著(P<0.001);不良反应发生率对比,治疗组患者住院期间出现恶心、呕吐、乏力、白细胞减少以及血小板降低等不良反应总发生率明显低于对照组(12.50%vs 37.50%)(P<0.05);临床疗效对比,两组患者客观有效率(ORR)比较无差异(55.00%vs 47.50%,χ^(2)=0.450,P>0.05),但治疗组疾病控制率(DCR)明显高于对照组(90.00%vs 72.50%,χ^(2)=4.021,P<0.05);生活质量对比,治疗后,治疗组患者KPS评分高于对照组(P<0.05);胃癌术后无进展生存时间对比,对照组患者平均FPS为(25.45±5.83)个月,中位PFS为(22.23±0.74)个月,治疗组患者平均FPS为(29.38±5.75)个月,中位PFS为(26.96±0.65)个月,治疗组明显高于对照组(P<0.05)。结论:胃癌患者术后采用四藤方加减联合化疗更能有效改善其不适症状,提高临床疗效与生活质量,从而延长无进展生存时间。
Objective: To investigate and analyze the effect of Modified Siteng Recipe combined with chemotherapy on progression free survival after gastric cancer surgery.Methods: 80 cases of gastric cancer patients who need surgical treatment in our hospital from October 2018 to July 2020 were selected as the research objects, and they were divided into controlled group(n=40) and treatment group(n=40) by digital parity method.Patients in the controlled group were treated with chemotherapy alone, while patients in the treatment group were treated with Modified Siteng Recipe on the basis of the controlled group.Both groups of patients were observed after 4 cycles of treatment TCM symptom score, incidence of adverse reactions, clinical efficacy, quality of life and progression free survival time were compared.Results: TCM symptom score comparison, the TCM symptom score of the treatment group decreased more significantly than that of the controlled group(P<0.001).The incidence of adverse reactions was compared, the total incidence of nausea, vomiting, fatigue, leucopenia and thrombocytopenia in the treatment group was significantly lower than that in the controlled group(12.50% vs 37.50%)(P<0.05).Comparison of clinical efficacy, the objective effective rate(ORR) of the two groups had no difference(55.00% vs 47.50%,χ^(2)=0.450,P>0.05),but the disease control rate(DCR) of the observation group was significantly higher than that of the controlled group(90.00% vs 72.50%,χ^(2)=4.021,P<0.05).Quality of life comparison, after treatment, the KPS score of the treatment group was higher than that of the controlled group(P<0.05).The mean FPS and PFS of the controlled group were(25.45±5.83) months, the median PFS was(22.23±0.74) months, the average FPS of the treatment group was(29.38±5.75) months, and the median PFS was(26.96±0.65) months in the treatment group, which was significantly higher than that in the controlled group(P<0.05).Conclusion: Modified Siteng Recipe combined with chemotherapy can effectively improve the symptoms
作者
汪莉
李铁
周正国
WANG Li;LI Tie;ZHOU Zhengguo(The Second People’s Hospital of Dalian City,Dalian Liaoning 116011,China)
出处
《四川中医》
2021年第3期96-99,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
胃癌
四藤方加减药物
化疗
无进展生存期
Gastric cancer
Modified Siteng Recipe
Chemotherapy
Progression free survival
