摘要
目的比较甲状旁腺全切除术(TPTX)联合腺体自体移植术(AT)与TPTX在治疗继发性甲状旁腺功能亢进(SHPT)中的应用效果。方法我院收治的76例尿毒症SHPT手术患者,根据治疗方法不同分为TPTX+AT组40例和TPTX组36例。比较两组手术相关指标、实验室指标、临床症状、并发症等。结果TPTX+AT组手术时间、住院时间长于TPTX组,术中出血量、住院费用高于TPTX组(P<0.05);随访6个月,TPTX+AT组血钙、血磷高于TPTX组,甲状旁腺激素(iPTH)低于TPTX组,低钙血症等并发症发生率低于TPTX组(P<0.05)。两组骨痛、皮肤瘙痒、肌无力、骨骼畸形比较,差异无统计学意义(P>0.05)。结论TPTX+AT治疗SHPT患者手术时间、术中出血量、住院时间、住院费用较长或较大,但在恢复实验室指标、减少并发症方面,有一定的优势。
Objective To compared the application effect between total parathyroidectomy with auto-transplantation(TPTX+AT)and total parathyroidectomy(TPTX)inthe treatment of secondary hyperparathyroidism(SHPT).Methods Clinical data of 76 SHPT patients with uremia were retrospectively analyzed.According to the treatment methods,the patients were divided into TPTX+AT group(n=40)and TPTX group(n=36).Operation related indexes,laboratory indexes,clinical symptoms and complications were compared between the two groups.Results The operative time and hospitalization time were longer and the intraoperative blood loss and hospitalization cost were higher in the TPTX+AT group than those in the TPTX group(P<0.05).Follow up for 6 months,blood calcium and phosphorus were higher while iPTH was lower as well as hypocalcemia complications were lower in the TPTX+AT group than those in the TPTX group(P<0.05).There was no statistically significant difference in bone pain,itchy skin,muscle weakness and skeletal deformity between two groups(P>0.05).Conclusion TPTX+AT treatment of SHPT,operation time,intraoperative blood loss,hospitalization time,and hospitalization costare longer or larger.However,it has a certain comparative advantages in the recovery of laboratory indicators andthe reduction of complications.
作者
尚忠明
王寓平
邱国春
张菠
SHANG Zhong-ming;WANG Yu-ping;QIU Guo-chun;ZHANG Bo(Department of Thyroid and Mammary Vascular Surgery,Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical University,Luzhou 646000,China)
出处
《实用医院临床杂志》
2021年第3期48-51,共4页
Practical Journal of Clinical Medicine
基金
西南医科大学—泸州市政府科研青年基金资助项目(编号:2017-ZRQN-122)。
