摘要
目的了解不同年龄段婴幼儿重症肺炎的病原体分布,为儿童重症肺炎早期诊断、精准治疗提供依据。方法应用宏基因组测序技术对2019年4月至2020年1月入住本院PICU的重症肺炎患儿肺泡灌洗液进行病原学检测,并对结果进行分析。结果77例重症肺炎儿童肺泡灌洗液病原检测阳性73例,总阳性率94.8%。小于6个月年龄组以呼吸道合胞病毒为主,占比15.3%;6个月~2岁和2~5岁组均以腺病毒7型为主,占比分别为30.4%和46.0%;大于5岁组以肺炎支原体为主,占比33.0%。结论广东地区儿童重症肺炎病原菌在6个月以下仍以呼吸道合胞病毒为主,经生殖道产时感染比例在此年龄段亦较高。6个月~5岁以腺病毒7型常见,大于5岁则以肺炎支原体常见。
Objective To understand the pathogen distribution of severe pneumonia in infants of different ages,and to provide evidences for early diagnosis and accurate treatment of severe pneumonia in children.Methods The pathogens of bronchoalveolar lavage fluid(BALF)of children with severe pneumonia admitted to PICU of our hospital from April,2019 to January,2020 was detected by metagenomic sequencing technology,and the results were analyzed.Results Among the 77 children with severe pneumonia,73 cases were positive for pathogens in bronchoalveolar lavage fluid(BALF),and the total positive rate was 94.8%.Respiratory syncytial virus(RSV)was predominant in the patients younger than 6 months,accounting for 15.3%.Adenovirus type 7 was predominant in the 6-month-to-2-year-old and 2-to-5-year-old groups,accounting for 30.4%and 46.0%,respectively.Mycoplasma pneumoniae was the main pathogen in the group over 5 years old,accounting for 33.0%.Conclusion RSV is still the main pathogen of severe pneumonia in children under 6 months old in Guangdong Province,and the proportion of intrapartum infection through reproductive tract is high in this age group.Adenovirus type 7 is common in 6 months to 5 years old children,and Mycoplasma pneumoniae is common in patients over 5 years old.
作者
姚仲伟
李美锦
林虹
苏淑芬
吴松
韩争争
郑亦男
Yao Zhongwei;Li Meijin;Lin Hong;Su Shufen;Wu Song;Han Zhengzheng;Zheng Yinan(PICU,Guangdong Maternal and Child Health Care Hospital,Guangzhou 511400,China)
出处
《国际医药卫生导报》
2021年第7期1023-1026,共4页
International Medicine and Health Guidance News
关键词
宏基因组测序技术
儿童
重症肺炎
病原
Metagenomic next generation sequencing
Children
Severe pneumonia
Pathogens
