摘要
目的:观察补肾通痹化纤方治疗特发性肺间质纤维化(idiopathic pulmonary fibrosis,IPF)的临床疗效。方法:将90例IPF患者随机分为对照组和试验组各45例,对照组给予乙酰半胱氨酸片治疗,试验组在对照组治疗的基础上加用补肾通痹化纤方治疗,日1剂,水冲服。两组患者均以30 d为1个疗程,共治疗3个疗程。观察两组患者临床疗效、肺功能指标、血液流变学指标、6分钟步行距离、圣乔治呼吸问卷(stgeorge′s respiratory questionnaire,SGRQ)评分变化情况。结果:对照组有效率为53.33%,试验组有效率为68.89%,两组有效率比较,差异有统计学意义(P<0.05)。两组治疗后一秒用力呼气容积(forced expiratory volume in one second,FEV1)、最大肺活量(maximum vital capacity,FVC)、呼气流量峰值(peak expiratory flow,PEF)水平与治疗前比较,差异无统计学意义(P>0.05),组间比较,差异无统计学意义(P>0.05)。对照组治疗后全血高切黏度、全血低切黏度、血浆黏度与治疗前比较,差异无统计学意义(P>0.05),试验组治疗后与治疗前比较,差异有统计学意义(P<0.05),组间比较,差异有统计学意义(P<0.05)。两组患者治疗后SGRQ评分、6分钟步行距离与治疗前比较均明显改善(P<0.05),且试验组改善程度明显优于对照组,具有统计学意义(P<0.05)。结论:补肾通痹化纤方可以改善IPF患者临床症状、SGRQ评分、6分钟步行距离及血液流变学指标,但对肺功能改善不明显。
Objective:To observe the clinical curative effect of Kidney-Supplementing and Arthralgia-Dredging and Fibrosis-Removing Decoction on idiopathic pulmonary fibrosis(IPF).Methods:A total of 90 patients with IPF were randomly divided into the control group and the experimental group,with 45 cases in each group.The control group was treated with Acetylcysteine Tablets,while the experimental group was treated with Kidney-Supplementing and Arthralgia-Dredging and Fibrosis-Removing Decoction on the basis of the control group,one dose a day.Two groups of patients were treated with 30 days as a course of treatment,a total of 3 courses of treatment.The clinical efficacy,pulmonary function indexes,hemorheology indexes,6-minute walking distance and SGRQ score of the two groups were observed.Results:The effective rate was 53.33%in the control group and 68.89%in the experimental group,and the difference was statistically significant(P<0.05).There was no significant difference in FEV1,FVC and PEF levels between the two groups after treatment compared with before treatment(P>0.05).There was no significant difference in the above indexes between the two groups after treatment(P<0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity of the control group had no significant difference compared with those before treatment(P>0.05),while the above indexes in the experimental group had significant difference compared with those before treatment(P<0.05),and there were significant differences between the two groups after treatment,(P<0.05).The SGRQ score and 6-minute walking distance of the two groups were significantly improved after treatment(P<0.05),and the improvement degree of the experimental group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Kidney-Supplementing and Arthralgia-Dredging and Fibrosis-Removing Decoction can improve the clinical symptoms,SGRQ score,6-minute walking distance and hemorheo
作者
王洪洋
李平
WANG Hong-yang;LI Ping(Shandong University of Chinese Medicine,Jinan,Shandong,China,250355;Tai'an Hospital of Traditional Chinese Medicine,Tai'an,Shandong,China,271000)
出处
《河南中医》
2021年第5期742-745,共4页
Henan Traditional Chinese Medicine
基金
山东省泰安市科技局农村与社会发展项目(2015NS1120)。
关键词
特发性肺间质纤维化
补肾通痹化纤方
乙酰半胱氨酸片
肺功能
血液流变学
SGRQ评分
6分钟步行距离
idiopathic pulmonary fibrosis(IPF)
Kidney-Supplementing and Arthralgia-Dredging and Fibrosis-Removing Decoction
Acetylcysteine Tablets
pulmonary function
hemorheology
SGRQ score
6-minute walking distance
