摘要
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种病因复杂、与年龄相关的肺纤维化疾病,其发病过程表现出进行性与不可逆性,最终导致患者呼吸系统衰竭而死亡。近些年的研究证实自噬参与了IPF的发生发展。本文回顾总结了自噬和IPF相关的临床研究、动物和细胞模型研究以及基于自噬的药物治疗研究,希望对阐明IPF的病理机制和药物研发有所帮助。
Idiopathic pulmonary fibrosis(IPF)is a kind of age-related pulmonary fibrosis disease with complex etiology.The pathogenesis of IPF is progressive and irreversible,which eventually leads to respiratory failure and death.In recent years,autophagy has been proved to be involved in the development of IPF.This review summarized the clinical research,animal and cell model research related to autophagy and IPF,and the drug treatment research based on the autophagy.It is hoped that this review will be helpful to clarify the pathological mechanism and drug development of IPF.
作者
王栋
颜培正
陈海红
徐梦真
张庆祥
朱庆均
WANG Dong;YAN Peizheng;CHEN Haihong;XU Mengzhen;ZHANG Qingxiang;ZHU Qingjun(Shandong University of Traditional Chinese Medicine,School of Pharmaceutical Sciences,Jinan 250355,China;Shandong University of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan 250355,China;Shandong University of Traditional Chinese Medicine,Innovative Institute of Chinese Medicine and Pharmacy,Jinan 250355,China;Key Laboratory of Traditional Chinese Medicine Classic Theory,Ministry of Education,Jinan 250355,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2021年第6期756-761,共6页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81774169)
山东省中医药科技发展计划项目(2019-0040)
山东省医药卫生科技发展计划(2018WS207)。
关键词
自噬
特发性肺纤维化
临床研究
动物细胞模型研究
autophagy
idiopathic pulmonary fibrosis
clinical research
animal and cell models
