摘要
急性呼吸窘迫综合征(ARDS)是临床常见的危重症之一,病死率达35%~40%。ARDS常由创伤、严重感染、休克、中毒或手术等因素进一步继发瀑布性全身炎症所致,发病机制复杂,其中凝血与纤溶功能的异常贯穿ARDS整个病程,早期促凝机制增强,介导微血栓产生及炎症放大。随着病程发展,纤溶系统的功能障碍致使纤维蛋白沉着增加。凝血及纤溶异常的预防和治疗在病程的转归中发挥重大的作用。文章主要就近年来ARDS中凝血功能及治疗等研究进展进行综述。
Acute respiratory distress syndrome(ARDS)is one of the most common critical illnesses in the clinic,with a case fatality rate as high as 35%-40%.ARDS is often caused by trauma,severe infection,shock,poisoning or surgery and further secondary waterfall systemic inflammation.The pathogenesis is complicated,and the abnormalities of coagulation and fibrinolysis function involve in the entire course of ARDS.In the early stage,the procoagulant mechanism is enhanced,mediating the generation of microthrombosis and the amplification of inflammation.As the disease progresses,the dysfunction of the fibrinolytic system leads to an increase in fibrin deposition.Therefore,the prevention and treatment of abnormal blood coagulation and fibrinolysis play an important role in the prognosis of the disease.The article will summarize the research progress on coagulation function and treatment in ARDS in recent years.
作者
张鹏(综述)
聂时南(审校)
ZHANG Peng;NIE Shi-nan(Department of Emergency,Jinling Hospital,Nanjing University School of Medicine,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2021年第5期555-560,共6页
Journal of Medical Postgraduates
关键词
急性呼吸窘迫综合征
凝血功能
炎症
acute respiratory distress syndrome
coagulation
inflammation
