摘要
目的探究痛风急性发作期糖类抗原72-4(CA72-4)升高患者的临床特点。方法选取2017年7月至2018年12月本院风湿免疫科门诊收治的急性痛风发作患者63例作为研究对象,以CA72-4高于正常值患者作为CA72-4升高组(n=43),CA72-4在正常范围作为对照组(n=20)。比较CA72-4升高组和对照组基线时期(痛风急性发作期)及治疗后(痛风缓解期)的临床资料、C-反应蛋白(CRP)、生化指标及CA72-4水平等。结果基线时期,CA72-4升高组CA72-4水平明显高于对照组(P<0.05)。CA72-4升高组年龄、病程与对照组比较差异无统计学意义。CA72-4升高组发作关节数少于对照组,差异有统计学意义(P<0.05)。CA72-4升高组中年龄>55岁患者基线时期CA72-4水平明显高于≤55岁(P<0.05),治疗后,CA72-4水平均明显降低。单关节及多关节患者基线时期和治疗后CA72-4水平比较差异均无统计学意义。治疗后,无论患者是否使用秋水仙碱CA72-4水平均较基线时期明显下降。排泄不良型及混合型患者基线时期CA72-4水平明显高于尿酸生成过多型(P<0.05);治疗后,各类型CA72-4水平比较差异无统计学意义。治疗前后,CRP水平正常患者与CRP水平升高患者CA72-4水平比较差异无统计学意义。结论痛风患者急性发作期CA72-4水平升高与关节发作数相关,与是否使用秋水仙碱无关,尿酸排泄不良型患者更易在急性发作期合并CA72-4水平升高,痛风患者CA72-4水平升高可能与患者急性炎症状态相关。
Objective To investigate the clinical characteristics of patients with elevated CA72-4 in acute gout attack.Methods From July 2017 to December 2018,63 patients with acute gout attack in the outpatient Department of Rheumatology and immunology of our hospital were selected.Patients with CA72-4 higher than the normal value were taken as the CA72-4 elevation group(n=43),and CA72-4 in the normal range was taken as the control group(n=20).The clinical data,C-reactive protein,biochemical indexes and CA72-4 levels in the baseline period(acute onset of gout)and after treatment(remission of gout)of the elevated CA72-4 group and the control group were compared.Results In the baseline period,the CA72-4 level in the CA72-4 increased group was significantly higher than that in the control group(P<0.05).There was no significant difference in age and course of disease between the CA72-4 elevation group and the control group.The number of joints in the elevated CA72-4 group was less than that in the control group,and the difference was statistically significant(P<0.05).The level of CA72-4 in patients with age>55 years old was significantly higher than that in patients with age≤55 years old(P<0.05).After treatment,CA72-4 levels were decreased.According to the number of joint attacks,there was no significant difference between two groups.After treatment,the level of CA72-4 was significantly lower than that in the baseline period whether the patients were treated with colchicine or not.The level of CA72-4 in patients with poor excretion and mixed type was significantly higher than that in patients with excessive uric acid generation(P<0.05).After treatment,there was no significant difference in CA72-4 levels among different uric acid excretion types.There was no significant difference in CA72-4 level between patients with normal CRP level and elevated CRP level.Conclusion The elevated level of CA72-4 in patients with gout during acute attack should be related to the number of joint attacks,rather than the use of colchicine.Patien
作者
杨亚旭
张芳
YANG Yaxu;ZHANG Fang(Department of Rheumatic Immunology,Affiliated Hospital of Integrated Traditional Chinese andWestern Medicine,Nanjing University of Chinese Medicine(Jiangsu Province Hospital on Integration of Chinese andWestern Medicine),Nanjing,Jiangsu,210028,China)
出处
《当代医学》
2021年第14期74-77,共4页
Contemporary Medicine
