摘要
目的探讨子痫前期(PE)患者外周血血清C1q/肿瘤坏死因子相关蛋白3(CTRP3)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)水平与PE病情的相关性。方法选取2018年10月至2019年12月本院妇产科收治的PE患者84例作为研究对象,按病情严重程度分为轻度组(49例),重度组(35例)。另选取同期健康妊娠孕妇40例纳入健康组。比较3组外周血血清CTRP3、CTRP9、可溶性血管内皮生长因子受体-1(s Flt-1)水平,分析3者与PE病情严重程度的相关性。测定3组外周血糖脂相关指标甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL)及胰岛素抵抗指数(HOMA-IR)水平,pearson分析其与CTRP3、CTRP9、s Flt-1水平相关性。对不同妊娠结局PE患者血清CTRP3、CTRP9、sFlt-1水平进行比较。结果重度组患者CTRP3、CTRP9水平明显低于轻度组,sFlt-1水平明显高于轻度组,TG、TC、LDL、HOMA-IR水平明显高于轻度组,差异均有统计学意义(P<0.05)。PE患者CTRP3、CTRP9水平与TG、TC、HOMA-IR呈负相关(P<0.05),sFlt-1水平与TG、TC、LDL、HOMA-IR呈正相关(P<0.05)。轻度组不良妊娠结局发生率为28.57%,明显低于重度组的51.43%,差异有统计学意义(P<0.05)。不良妊娠结局PE患者CTRP3、CTRP9水平相比无不良妊娠PE患者明显降低,sFlt-1水平明显升高,差异均有统计学意义(P<0.05)。结论外周血CTRP3、CTRP9水平与PE患者病情严重程度及妊娠结局密切相关,检测二者水平对于缓解该病进展及降低妊娠不良结局发生率有积极意义。
Objective To explore the correlation between serum C1 q tumor necrosis factor-related protein 3(CTRP3),CTRP9 levels in peripheral blood and the severity in patients with preeclampsia(PE).Methods A total of 84 PE patients admitted to the Department of Obstetrics and Gynecology in our hospital from October 2018 to December 2019 were enrolled as the research objects.According to disease severity,they were divided into the mild group(49 cases)and the severe group(35 cases).Another 40 healthy pregnant women were enrolled as the healthy group.The levels of serum CTRP3,CTRP9 and soluble soluble vascular endothelial growth factor receptor-1(sFlt-1)in peripheral blood were compared among the three groups.And the correlation among the three indicators and PE severity was analyzed.The levels of peripheral blood glucose-lipid related indexes[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL),homeostasis model assessment of insulin resistance(HOMA-IR)]in the three groups were detected.And their correlation with CTRP3,CTRP9 and sFlt-1 was analyzed by Pearson.The serum CTRP3,CTRP9 and sFlt-1 levels of PE patients with different pregnancy outcomes were compared.Results The levels of CTRP3 and CTRP9 in the severe group were significantly lower than those in the mild group,s Flt-1 level was significantly higher than that in the mild group,and levels of TG,TC,LDL and HOMA-IR were significantly higher than those in the mild group(P<0.05).The levels of CTRP3 and CTRP9 were negatively correlated with TG,TC and HOMA-IR(P<0.05),while s Flt-1 level was positively correlated with with TG,TC,LDL,and HOMA-IR(P<0.05).The incidence of adverse pregnancy outcomes in the mild group was significantly lower than that in the severe group(28.57%vs 51.43%)(P<0.05).The levels of CTRP3 and CTRP9 in PE patients with adverse pregnancy outcomes were significantly lower than those without adverse pregnancy outcomes,and the level of s Flt-1 was significantly increased,and the difference was statistically significant(P<0.05).Conc
作者
吴梦菲
蒋瑶
张亚慧
贾素红
WU Mengfei;JIANG Yao;ZHANG Yahui;JIA Suhong(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Suzhou University,Suzhou,Jiangsu,China,215000)
出处
《分子诊断与治疗杂志》
2021年第4期551-554,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏省重点研发计划资助项目(BE2018652)。
