摘要
目的:探讨中性粒细胞与淋巴细胞比值(NLR)和血小板计数(PLT)预测慢性难愈性创面术后感染的价值。方法:回顾性分析经过手术治疗的慢性难愈性创面患者120例,根据国际伤口感染研究所(IWII)提出的局部伤口感染临床表现分为未感染组(65例)和感染组(55例)。比较两组一般资料和血液参数。慢性创面术后感染的危险因素采用Logistic回归分析。利用受试者工作特征(ROC)曲线评估NLR和PLT对慢性创面术后感染的预测价值。结果:感染组白细胞计数、PLT、中性粒细胞计数、NLR、PLR和糖尿病患者占比高于未感染组(均P<0.05)。以慢性创面术后发生感染为因变量,以糖尿病(无=0,有=1)、白细胞计数、中性粒细胞计数、淋巴细胞计数、平均血小板体积,NLR、PLT、PLR为自变量,进行Logistic回归分析,显示PLT和NLR是慢性创面术后感染的独立危险因素(均P<0.05)。ROC曲线分析显示,NLR、PLT预测患者慢性创面术后感染的曲线下面积分别为0.818、0.802,最佳诊断截点分别为2.34、248.5×10^(9)/L,敏感性分别为80.0%、74.5%,特异性分别为75.4%、81.5%。结论:NLR和PLT对慢性难愈性创面术后感染具有一定预测价值。
Objective:To explore the value of neutrophil to lymphocyte ratio(NLR)and platelet count(PLT)in predicting postoperative infection of chronic refractory wounds.Methods:A retrospective analysis of 120 patients with chronic refractory wounds who underwent surgical treatment was divided into non-infected group(65 cases)and infected group(55 cases).The general data and blood indicators of the two groups were compared.Logistic regression was used to analyze the risk factors of postoperative infection in chronic wounds.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of NLR and PLT for postoperative infection of chronic wounds.Results:The white blood cell count,PLT,neutrophil count,lymphocyte count,mean platelet volume,NLR,PLR and the proportion of diabetes in the non-infected group were higher than those in the infected group(all P<0.05).Taking postoperative infection after chronic wounds as the dependent variable,diabetes,white blood cell count,neutrophil count,lymphocyte count,average platelet volume,NLR,PLT as independent variables,and Logistic regression analysis showed that PLT and NLR were independent risk factors for postoperative infection of chronic wounds(all P<0.05).ROC curve analysis showed that the area under the curve for NLR and PLT to predict postoperative infection of patients with chronic wounds were 0.818 and 0.802,respectively.The best diagnostic cut-off values were 2.34 and 248.5×10^(9)/L,and the sensitivities were 80.0%and 74.5%,and the specificities were 75.4%and 81.5%,respectively.Conclusion:NLR and PLT have certain predictive value for postoperative infection of chronic refractory wounds.
作者
杨文静
刘宾
崔鑫
马戈甲
韩悦
任杰
YANG Wenjing;LIU Bin;CUI Xin;MA Gejia;HAN Yue;REN Jie(Medical School of Yan’an University,Yan’an 716000,China)
出处
《陕西医学杂志》
CAS
2021年第5期546-549,共4页
Shaanxi Medical Journal
基金
陕西省科技厅社会发展攻关项目(2020SF-184)。
