摘要
目的比较超声造影(CEUS)对无肝硬化背景的肝内胆管细胞癌(ICC)与肝脏炎性病灶的诊断价值。方法选择2018年1月至2019年1月收治的100例无肝硬化背景ICC患者作为观察组,另选取同期100例肝脏炎性病灶患者作为对照组,均实施CEUS及病理诊断。比较两组的检出率、CA199、DKK1水平及诊断结果。结果观察组的检出率高于对照组,差异具有统计学意义(P<0.05)。观察组的CA199、DKK1水平均高于对照组,差异具有统计学意义(P<0.05)。ICC、肝脏炎性病灶在动脉期均呈边界不清;时间-强度曲线分析显示,ICC开始廓清时间为(34.51±3.51)s,明显早于炎性病灶的(62.71±12.60)s,差异具有统计学意义(P<0.05);注射造影剂3 min时病灶内部与周围肝实质强度差值:ICC为(10.15±1.27)dB,大于炎性病灶的(3.17±1.08)dB,差异具有统计学意义(P<0.05)。结论 CEUS对无肝硬化背景的ICC患者的诊断价值显著,具有较高的检出率,可为患者后期治疗提供依据,值得临床推广及应用。
Objective To compare the values of contrast enhanced ultrasound(CEUS)in the diagnosis of intrahepatic cholangiocarcinoma(ICC)without cirrhosis background and liver inflammatory lesions.Methods A total of 100 ICC patients without cirrhosis background admitted from January 2018 to January 2019 were selected as observation group,and another 100 patients with inflammatory liver lesions during the same period were selected as control group.CEUS and pathological diagnosis were performed on all patients.The detection rate,CA199,DKK1 levels and diagnostic results were compared between the two groups.Results The detection rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of CA199 and DKK1 in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The boundary of ICC and liver inflammatory lesions were not clear in arterial phase;the time-intensity curve analysis showed that the clearance time of ICC was(34.51±3.51)s,which was significantly earlier than(62.71±12.60)s of inflammatory lesions,and the difference was statistically significant(P<0.05);the difference of the intensity between the liver parenchyma inside and around the lesion was(10.15±1.27)dB in ICC,which was greater than(3.17±1.08)dB of inflammatory lesions,and the difference was statistically significant(P<0.05).Conclusion CEUS has significant diagnostic value for ICC patients without cirrhosis background,with high detection rate,it can provide basis for later treatment of patients,which is worthy of clinical promotion and application.
作者
黄金龙
张利群
HUANG Jinlong;ZHANG Liqun(Hanzhong Central Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2021年第13期132-134,共3页
Clinical Research and Practice
关键词
肝硬化
肝内胆管细胞癌
肝脏炎性病灶
超声造影
病理诊断
cirrhosis
intrahepatic cholangiocarcinoma
liver inflammatory lesions
contrast enhanced ultrasound
pathological diagnosis
