摘要
探究儿童单纯性肥胖对甲状腺激素变化的影响,为干预儿童单纯性肥胖、改善肥胖儿童生活质量,提供理论依据。儿童肥胖与甲状腺功能变化密切相关,肥胖儿童促甲状腺激素水平较普通儿童高,其机制目前公认的假说与瘦素相关。促甲状腺激素轻度升高更像是体质量增加的适应性改变,而不是引起肥胖的原因。选择性甲状腺激素受体激动剂将来可能成为治疗肥胖的潜在药物,能否应用于儿童肥胖治疗,仍有待更多的临床研究加以验证。
To explore the changes of thyroid hormones in children with simple obesity,and to provide theoretical basis for the treatment of simple obesity and improving the quality of life of obese children.Child obesity is closely related to changes in thyroid function.Obese children have higher levels of thyroid-stimulatinghormone(TSH)than ordinary children.The currently accepted hypothesis shows that its mechanism is related to leptin.A mild increase in TSH is more like an adaptive change in body weight,rather than a cause of obesity.Selective thyroid hormone receptor agonist may become a potential drug for the treatment of obesity in the future.It remains to be verified by more clinical studies whether it can be used in the treatment of childhood obesity.
作者
王诗佳
刘庆阳
WANG Shijia;LIU Qingyang(Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China)
出处
《中国中西医结合儿科学》
2021年第2期108-111,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
辽宁省自然科学基金博士启动基金项目(20161191)
辽宁省教育厅基础研究项目(L202007)。
