摘要
目的分析甲状腺功能与核磁共振测定的腹部皮下脂肪及内脏脂肪面积的相关性，探讨甲状腺功能对腹部脂肪分布的影响。方法随机选取763名沈阳市南站社区40至65岁居民为研究对象，进行问卷调查，测量身高、体重、腰围、臀围、血压、体脂含量，测定空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL－C）、低密度脂蛋白胆固醇（LDL－C）、空腹胰岛素（FINS）、口服葡萄糖耐量试验2h血糖（OGTF2hPG）、促甲状腺激素（TSH）、游离甲状腺素（FT４）、游离三碘甲状腺原氨酸（FT３）及甲状腺过氧化物酶抗体（TPOAb）。应用核磁共振测定腹部皮下脂肪面积及内脏脂肪面积。应用Pearson相关检验及多因素线性回归模型进行数据分析。结果Pearson相关分析显示，lnTSH与皮下脂肪呈正相关（r=0．183，P〈0．05），而与内脏脂肪无相关性。FT4与皮下脂肪呈负相关（r=－0．164，P〈0．05），与内脏脂肪呈正相关（r=0．118，P〈0．05）。FＴ３与皮下脂肪呈负相关（r=－0．098，P〈0．05），与内脏脂肪呈正相关（r=0．261，P〈0．05）。将Pearson相关分析中与皮下脂肪或内脏脂肪有相关的变量代人多因素线性回归模型，结果显示收缩压、lnTSH及兀’，是影响皮下脂肪的危险因素，而BMI、腰围、血尿酸及OGTT2h血糖是影响内脏脂肪的危险因素。结论流行病学的横断面研究结果显示血清TSH增高及正常范围内的FＴ３，降低是预测皮下脂肪面积的危险因素，提示血清TSH及FＴ３可能在体内脂肪的分布上发挥着一定的作用。
Objective To analysis the correlation between thyroid function and abdominal subcutaneous fat and visceral fat determined by magnetic resonance image （MRI） senning, and to investigate the influence of thyroid function on abdominal fat distribution. Methods 763 residents aged between 40 and 65 years old were randomly selected from South Station community. A detailed questionnaire and physical examination, height, weight, waist circumference, hip circumference, blood pressure was conducted. Body mass index and waist to hip ratio were calculated. ＂Tanita TBF 300A＂ body fat component instrument was used to measure body fat. Fasting blood was collected to test fasting blood glucose, total cholesterol, triglyeerides, high density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting insulin, TSH, FT4 , FT3 and TPOAb. Oral glucose tolerance test was performed. MRI scan was conducted to measure the subcutaneous fat （SF） and visceral fat （VF） area. Results Pearson correlation analysis showed that LnTSH and SF were positively correlated （ r = 0. 183, P 〈 0. 05 ） , but no correlation was found between LnTSH and VF. FF4 and SF were negatively correlated （r = -0. 164, P 〈 0.05 ） , and FT4 was positively correlated with VF （r = 0. 118, P 〈 0.05 ）. FT3 and SF were negatively correlated （r = -0. 098, P 〈 0. 05 ）, and FT3 was positively correlated with VF （ r = 0. 261, P 〈 0. 05 ）. Variables relevant to SF or VF area in single correlation model were put into the regression model, and the results showed that systolic blood pressure （SBP）, LnTSH and FT3 were risk factors of SF area. While BMI, waist circumference, blood uric acid and OGTY 2 h blood glucose were risk factors of VF area. Conclusion The cross-sectional epidemiological study showed serum TSH elevation and FT3 decrease were risk factors of SF area, which indicated serum TSH and FT3 may play a certain role in the distribution of body fat.
出处
《中华糖尿病杂志》
CAS
CSCD
2013年第12期734-739,共6页
CHINESE JOURNAL OF DIABETES MELLITUS
基金
“十一五”国家科技支撑计划项目（2009BAl80801）
辽宁省教育厅科研研究一般项目（L2012275）
