摘要
目的探讨盐酸替罗非班对冠心病治疗的有效性。方法选取2018年6月~2020年6月辽宁省健康产业集团铁煤总医院收治的88例冠心病患者作为研究对象,按照奇偶数分组法分为对照组(44例)、试验组(44例),对照组采用常规治疗方法,试验组在常规治疗基础上加用盐酸替罗非班治疗。比较两组的治疗总有效率、心功能、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平及不良事件发生情况。结果试验组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组的每分输出、射血分数及每搏量高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组的Hcy、hs-CRP水平低于对照组,差异有统计学意义(P<0.05)。试验组的不良事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论盐酸替罗非班治疗冠心病可显著提高临床疗效,改善心功能,减轻机体炎症反应,减少不良事件发生。
Objective To explore the effectiveness of Tirofiban Hydrochloride in the treatment of coronary heart disease.Methods A total of 88 patients with coronary heart disease admitted to the Iron Coal General Hospital of Liaoning Health Industry Group from June 2018 to June 2020 were selected as the research objects.They were divided into a control group(44 cases)and a test group(44 cases)by the odd and even number grouping method.The control group used conventional treatment,and the test group was treated with Tirofiban Hydrochloride on the basis of conventional treatment.The treatment efficiency,cardiac function,homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP)levels and the rate of adverse events were compared between the two groups.Results The total effective rate of the test group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the output per minute,ejection fraction and stroke volume of the test group were higher than those of the control group,the differences were statistically significant(P<0.05).The levels of Hcy and hs-CRP in the test group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence rate of adverse events in the test group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Tirofiban Hydrochloride in the treatment of coronary heart disease can significantly improve the clinical efficacy,improve heart function,reduce the body′s inflammatory reaction,and reduce the occurrence of adverse events.
作者
程乾堃
CHENG Qian-kun(Departmen of Circulatory Medicine,Iron Coal General Hospital of Liaoning Health Industry Group,Liaoning Province,Tieling112700,China)
出处
《中国当代医药》
CAS
2021年第12期144-146,共3页
China Modern Medicine
关键词
盐酸替罗非班
冠心病
治疗有效性
心功能
Tirofiban Hydrochloride
Coronary heart disease
Therapeutic effectiveness
Cardiac Function
