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盐酸替罗非班治疗冠心病的临床疗效及其安全性 被引量:3

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摘要 目的探讨盐酸替罗非班治疗冠心病的临床疗效及其安全性。方法选取怀化市第一人民医院2017年2月13日—2018年2月13日收治的冠心病患者120例,随机分为对照组和观察组,各60例。对照组给予皮下注射低分子肝素治疗,观察组给予盐酸替罗非班治疗。比较2组临床疗效,治疗前后基质金属蛋白酶9(MMP-9)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆凝血酶原时间(PT)、左心室射血分数(LVEF)、左心室收缩末期容积(ESV)、左心室舒张末期容积(EDV),并比较2组不良反应发生率。结果观察组总有效率高于对照组(P<0.05)。治疗后观察组MMP-9、APTT、TT、PT低于对照组(P<0.05)。治疗后观察组LVEF、EDV高于对照组,ESV低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论盐酸替罗非班治疗冠心病的临床疗效确切,能够抑制血小板聚集,降低缺血再灌注心肌损伤,有效抗血栓和抗血小板,稳定活动斑块,且安全性较高。
作者 蒋军军
出处 《临床合理用药杂志》 2021年第6期51-53,共3页 Chinese Journal of Clinical Rational Drug Use
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