摘要
目的观察针刺放血联合镇肝熄风汤治疗肝阳上亢型偏头痛的疗效及对降钙素基因相关肽(CGRP)、前列腺素E_(2)(PGE_(2))的影响。方法将128例肝阳上亢型偏头痛患者按照随机数字表法分为2组。对照组64例予镇肝熄风汤治疗,治疗组64例在对照组治疗基础上联合针刺放血治疗。2组均治疗3周。比较2组治疗前后头痛发作次数、头痛持续时间,治疗前及治疗1、2、3周疼痛视觉模拟评分(VAS),治疗前后头痛残疾程度评估问卷(MIDAS)评分及治疗前、治疗后1、3、6个月血清CGRP、PGE_(2)变化,并统计疗效。结果治疗组总有效率98.4%(63/64),对照组总有效率89.1%(57/64),治疗组疗效优于对照组(P<0.05)。治疗后2组头痛发作次数及持续时间均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗1、2、3周2组疼痛VAS均较本组治疗前降低(P<0.05),且治疗1、2、3周治疗组均低于对照组(P<0.05)。治疗后2组MIDAS评分均较本组治疗前降低(P<0.05),且治疗后治疗组低于对照组(P<0.05)。治疗后1、3、6个月2组血清CGRP、PGE_(2)水平均较本组治疗前降低(P<0.05),治疗后3、6个月均低于治疗后1个月(P<0.05),且治疗后1、3、6个月治疗组均低于对照组同期(P<0.05)。结论针刺放血联合镇肝熄风汤治疗肝阳上亢型偏头痛可抑制血清CGRP及PGE_(2)的释放,发挥镇痛作用,改善患者的临床症状,提高治疗效果。
Objective To explore the effect on Therapeutic Effect of Acupuncture and Bloodletting Combined with Zhengan Xifeng Decoction on Liver-yang Hyperactivity Migraine and Its Effect on Calcitonin Gene Related Peptide(CGRP)and Prostaglandin E_(2)(PGE_(2)).Methods Totally 128 patients with liver-yang hyperactivity migraine were randomly divided into therapy group and control group.The control group(n=64)was treated with Zhengan Xifeng decoction,and the therapy group(n=64)was treated with Zhengan Xifeng decoction combined with acupuncture and bloodletting;treatment with 3 weeks in two groups,aiming to compare the number and duration of headache attacks,pain VAS score,Migraine Disability Assessment questionnaire score(MIDAS),serum changes of CGRP,PGE_(2) between two groups before and after treatment,and count the treatment effects in two groups.Results After treatment,the total effective rate in the therapy group was 98.4%(63/64),which was significantly higher than 89.1%(57/64)in the control group(P<0.05);frequency and duration of headache attacks in both groups were lower than before treatment(P<0.05),and those in the therapy group were lower than the control group(P<0.05).After 1,2,3 weeks of treatment,VAS score and MIDAS score in the two groups were all lower than before treamtmant,and those in the therapy group were lower than the control group(P<0.05).After 1,2,3 months of treatment,the contents of CGRP and PGE_(2) in the two groups were lower than those before treatment(P<0.05),those in the therapy group were lower than thecontrol group(P<0.05),those in both groups after 2,3 months of treatment were lower than after 1 month of treatment(P<0.05).Conclusion Acupuncture and bloodletting combined with Zhengan Xifeng decoction can inhibit the release of serum CGRP and PGE_(2),play an immediate analgesic effect,improve the clinical symptoms of patients and improve the therapeutic effect.
作者
马昕宇
王麟鹏
刘慧林
王少松
刘璐
MA Xinyu;WANG Linpeng;LIU Huilin;WANG Shaosong;LIU Lu(Department of Acupuncture and Moxibustion,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010)
出处
《河北中医》
2021年第1期130-133,136,共5页
Hebei Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)(编号:2014CB543203)。
关键词
肝阳上亢
偏头痛
镇肝熄风汤
放血法
针刺疗法
Zhengan Xifeng Decoction
bloodletting
Liver-yang sputum type
Headache
