摘要
目的分析脑梗死患者认知障碍应用奥拉西坦治疗的评估。方法该院为了进行该次研究所选择的对象全部来自2018年9月—2020年3月期间收治的脑梗死患者中,一共为80例,根据随机的方式可以将患者分成观察组和对照组,每组40例。对照组主要接受常规治疗,观察组在常规治疗的基础上进行奥拉西坦治疗,对比两组患者的治疗效果、不良反应发生率、治疗前后的MMSE、MoCA及ADL评分、治疗前后P300指标、生活质量。结果观察组的治疗效果为95.0%,高于对照组的77.5%,差异有统计学意义(χ^(2)=5.165,P=0.020)。观察组的失眠、腹泻、恶心呕吐等不良反应发生率为7.5%,低于对照组的25.0%,差异有统计学意义(χ^(2)=4.501,P=0.034)。观察组治疗前后的MMSE、MoCA及ADL评分分别为(16.18±3.01)分、(24.69±1.54)分、(16.02±1.43)分、(25.85±2.86)分、(56.88±3.71)分、(87.56±2.74)分,治疗前与对照组数据相近,差异无统计学意义(P>0.05),治疗后对比差异有统计学意义(P<0.05)。观察组治疗前后P3、N2、P2等水平指标分别为(363.45±39.42)、(326.12±21.45)、(261.34±24.11)、(236.11±18.22)、(164.37±21.34)、(154.32±14.67)ms,治疗前与对照组数据相近,差异无统计学意义(P>0.05),治疗后对比,差异有统计学意义(P<0.05)。观察组的社会功能、躯体功能、角色功能、认知功能等生活质量分别为(86.48±2.18)分、(85.67±2.13)分、(86.37±2.55)分、(85.61±2.16)分,均要高于对照组,差异有统计学意义(t社会功能=36.630,t躯体功能=35.828,t角色功能=26.784,t认知功能=38.851,P<0.001)。结论脑梗死患者认知障碍应用奥拉西坦治疗的临床疗效显著,能够有效促进患者各项功能的恢复。
Objective To analyze the evaluation of oxiracetam for cognitive impairment in patients with cerebral infarction.Methods The subjects selected by the hospital for this study are all from the patients with cerebral infarction admitted from September 2018 to March 2020,a total of 80 cases.The patients can be divided into observation group and control group according to the random method,40 cases in each group.The control group mainly received conventional treatment,and the observation group was treated with oxiracetam on the basis of conventional treatment.The treatment effect,incidence of adverse reactions,MMSE,MoCA and ADL scores before and after treatment,P300 index,quality of life before and after treatment,were compared between the two groups of patients.Results The treatment effect of the observation group was 95.0%,which was higher than 77.5% of the control group,the difference was statistically significant(χ^(2)=5.165,P=0.020).The incidence of adverse reactions such as insomnia,diarrhea,nausea and vomiting in the observation group was 7.5%,which was lower than 25.0% in the control group,the difference was statistically significant(χ^(2)=4.501,P=0.034).The MMSE,MoCA and ADL scores of the observation group before and after treatment were(16.18±3.01)points、(24.69±1.54)points、(16.02±1.43)points、(25.85±2.86)points、(56.88±3.71)points、(87.56±2.74)points,and the data before treatment were similar to those of the control group,and the difference was not statistically significant(P>0.05),after treatment,the difference was statistically significant(P<0.05).The levels of P3,N2 and P2 in the observation group before and after treatment were(363.45±39.42)ms、(326.12±21.45)ms、(261.34±24.11)ms、(236.11±18.22)ms、(164.37±21.34)ms、(154.32±14.67)ms.The data before treatment was similar to that of the control group,and the difference was not statistically significant.(P>0.05),after treatment,which was statistically significant(P<0.05).The social function,physical function,role function,cognitive f
作者
邓瑜
DENG Yu(People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang Uygur Autonomous Region,830000 China)
出处
《世界复合医学》
2021年第3期188-191,共4页
World Journal of Complex Medicine
关键词
脑梗死
认知障碍
奥拉西坦
Cerebral infarction
Cognitive impairment
Oxiracetam
