摘要
目的评价右美托嘧啶对颅脑损伤(TBI)患者脑组织的作用。方法计算机检索PubMed、EMbase、Cochrane Library、WANFANG、CNKI、VIP和中国生物医学文献数据库,收集从建库至2020年1月有关右美托嘧啶治疗TBI患者的临床随机对照研究,仅限以英文及中文形式发表的文章,并对其进行质量评价,使用RevMan 5.3软件对收集的数据进行Meta分析。结果最终纳入18篇文献,共1543例患者,Meta分析结果示:右美托嘧啶组的血浆S100B蛋白(S100B)含量(SMD=-2.74,95%CI=-3,71~-1.78)、神经元特异性烯醇化酶(NSE)含量(SMD=-1.71,95%CI=-2.40~-1.03)、白介素6(IL-6)(SMD=-1.18,95%CI=-1.55~-0.81)含量及脑氧摄取率(CERO2)(MD=-8.71,95%CI=-15.19~-2.23)均低于对照组,其颈静脉血氧饱和度(SjvO2)(MD=5.73,95%CI=3.86~7.62)高于对照组,且差异均有统计学意义(P<0.05)。结论右美托嘧啶能抑制TBI生物学标志物的释放,稳定脑氧代谢水平,可能对TBI患者的脑组织起到保护作用。
Objective To evaluate the effect of dexmedetomidine on the brain tissue of patients with traumatic brain injury(TBI).Methods Computer search of PubMed,EMbase,Cochrane Library,WANFANG,CNKI,VIP and Chinese biomedical literature database,collect clinical randomized controlled studies on dexmedetomidine in the treatment of patients with TBI from the establishment of the database to January 2020,only articles published in English and Chinese,and evaluate their quality.RevMan 5.3 software is used to conduct the collected data Meta analysis.Results 18 literatures were finally included,with a total of 1543 patients.The results of the Meta analysis showed that the plasma S100B protein(S100B)content of the dexmedetomidine group(SMD=-2.74,95%CI=-3,71~-1.78),Neuron specific enolase(NSE)content(SMD=-1.71,95%CI=-2.40~-1.03),interleukin 6(IL-6)(SMD=-1.18,95%CI=-1.55~-0.81)content and cerebral oxygen uptake rate(CERO2)(MD=-8.71,95%CI=-15.19~-2.23)are lower than the control group,its jugular venous oxygen saturation(SjvO2)(MD=5.73,95%CI=3.86~7.62)was higher than the control group,the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine can inhibit the release of TBI biomarkers,stabilize the level of cerebral oxygen metabolism,and may have a protective effect on the brain tissue of patients with TBI.
作者
李飞扬
王建村
李雪峰
胡观成
LI Fei-yang;WANG Jian-cun;LI Xue-feng;HU Guan-cheng(Department of Neurosurgery,Zhangjiajie Hospital Affiliated to Hunan Normal University,Zhangjiajie 427000,Hunan,China;Department of Neurosurgery,Shanghai Pudong New Area People's Hospital,Shanghai 200120,China;Department of Neurosurgery,Zhangjiajie People's Hospital,Zhangjiajie 427000,Hunan,China)
出处
《医学信息》
2021年第8期89-94,共6页
Journal of Medical Information
关键词
右美托嘧啶
颅脑损伤
脑组织保护
Dexmedetomidine
Traumatic braininjury
Brain tissue protection
