摘要
目的分析心肺复苏后应用醒脑静注射液对心肺复苏后脑氧代谢、血清细胞因子的影响。方法采用随机数字表法将我院心肺复苏成功救治的120例患者随机分为实验组与对照组各60例,两组均予以西医常规处理,实验组在此基础上应用醒脑静注射液。比较两组患者心脏搏动恢复时、72h后脑氧代谢指标[颈静脉血氧饱和度(SjvO2)、脑氧摄取量(ERO2)、动脉-颈内静脉血氧含量差(Ca-jvO2)],血清细胞细胞因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、中枢神经特异蛋白(S-100β)]水平变化,以及全身炎症反应综合征(SIRS)发生率。结果心脏搏动恢复72h后,两组患者SjvO2均升高,但实验组低于对照组,ERO2、Ca-jvO2均降低,但实验组高于对照组(P<0.05);实验组S-100β、IL-10升高,TNF-α、IL-6降低,对照组S-100β、IL-10、TNF-α、IL-6均升高,实验组S-100β、TNF-α、IL-6低于对照组,IL-10高于对照组(P<0.05);实验组SIRS发生率低于对照组(P<0.05)。结论心肺复苏后应用醒脑静注射液,可抑制炎症反应,缓解脑组织再灌注损伤,于患者预后有利。
Objective To analyze the effects of Xingnaojing injection on cerebral oxygen metabolism and serum cytokines after cardiopulmonary resuscitation.Methods 120 patients successfully treated with cardiopulmonary resuscitation in our hospital were randomly divided into experimental group and control group according to the random number table method,with 60 cases in each group.The two groups were given routine Western medicine therapy,and experimental group was treated with Xingnaojing injection on this basis.The cerebral oxygen metabolism indexes[jugular vein blood oxygen saturation(SjvO2),cerebral oxygen uptake(ERO2),arterial-internal jugular vein blood oxygen content difference(Ca-jvO2)]and serum cytokines[tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),interleukin-6(IL-6),central nervous specific protein(S-100β)]at and after 72h of cardiac pulsation recoveryand the incidence rate of systemic inflammatory response syndrome(SIRS)were compared between the two groups.Results After 72h of cardiac pulsation recovery,the SjvO2 was increased in the two groups,but the index in experimental group was lower than that in control group,and the ERO2 and Ca-jvO2 were decreased,but the two indexes in experimental group were higher than those in control group(all P<0.05).The S-100βand IL-10 were increased while the TNF-αand IL-6 were decreased in experimental group,and the S-100β,IL-10,TNF-αand IL-6 all were increased in control group,and the S-100β,TNF-αand IL-6 in experimental group were lower than those in control group while the IL-10 was higher than that in control group(all P<0.05).The incidence rate of SIRS in experimental group was lower than that in control group(P<0.05).Conclusion The application of Xingnaojing injection after cardiopulmonary resuscitation can inhibit the body’s inflammatory response and reduce cerebral tissue reperfusion injury,and it is beneficial to the prognosis of patients.
作者
王慧
凌云
张沛
Wang Hui;Ling Yun;Zhang Pei(Department of Pharmacy,Zhengzhou First People’s Hospital,Zhengzhou 450000,China)
出处
《哈尔滨医药》
2021年第1期37-39,共3页
Harbin Medical Journal
关键词
心肺复苏
醒脑静注射液
脑氧代谢
炎症反应
Cardiopulmonary resuscitation
Xingnaojing injection
Cerebral oxygen metabolism
Inflammatory response
