摘要
目的分析童年创伤对缓解期双相情感障碍患者血浆中长链非编码RNA 51A(lncRNA 51A)表达及情绪认知功能的影响。方法选取缓解期双相情感障碍患者100例为研究组,其中有童年创伤34例,无童年创伤66例,另选取同期招募自愿参加本研究的健康人100名为对照组。使用儿童期创伤问卷及情绪面孔识别评估患者童年创伤及情绪认知功能,采用qRT-PCR法检测血浆lncRNA 51A表达水平。结果研究组儿童期创伤问卷总分及情感虐待(EA)、躯体虐待(PA)、性虐待(SA)、情感忽视(EN)和躯体忽视(PN)评分、血浆lncRNA 51A表达水平均高于对照组(P<0.05),情绪面孔识别中对悲伤、愤怒、高兴、惊讶、恐惧、厌恶识别正确率均低于对照组(P<0.05)。有童年创伤组血浆lncRNA 51A表达水平、童年创伤总分及EA、PA、SA、EN、PN评分均高于无童年创伤组,对悲伤、愤怒、高兴、惊讶、恐惧、厌恶识别正确率均低于无童年创伤组(P<0.05)。研究组血浆中lncRNA 51A水平与EA、SA、PA评分均呈正相关(P<0.05),与悲伤识别、恐惧识别正确率均呈负相关(P<0.05)。高汉密尔顿抑郁量表(HAMD)评分、高杨氏躁狂量表(YRMS)评分、高lncRNA 51A水平、童年创伤是影响缓解期双相情感障碍发生的危险因素(P<0.05)。结论缓解期双相情感障碍患者血浆lncRNA 51A表达水平升高,与EA、SA、PA等童年创伤评分及悲伤识别、恐惧识别正确率等情绪认知功能评价有关,可能作为有童年创伤缓解期双相情感障碍发生影响因素。
Objective To explore the effects of childhood trauma on plasma Long non-coding RNA 51A(lncRNA 51A)expression and emotional cognitive function in patients with remission bipolar disorder.Methods A total of 100 patients with bipolar disorder in remission in study group including 34 cases with childhood trauma and 66 cases without childhood trauma,and 100 healthy controls in control group were selected and assessed with Childhood Trauma Questionnaire(CTQ)and emotional face recognition.The expression of lncRNA 51A in plasma was detected by qRT-PCR.Results The total score and factor scores of emotional abuse(EA),physical abuse(PA),sexual abuse(SA),emotional neglect(EN)and physical neglect(PN)of CTQ and expression level of lncRNA 51A in study group were all significantly lower than those in control group(P<0.05);the correct recognition rates of sadness,anger,happiness,surprise,fear and aversion in study group were significantly lower than those in control group(P<0.05).The expression level of lncRNA 51A,the total score and factor scores of EA,PA,SA,EN,PN of CTQ in patients with childhood trauma were all significantly higher than those in patients without childhood trauma,and the correct recognition rates of sadness,anger,happiness,surprise,fear and aversion in patients with childhood trauma were all significantly lower than those in patients without childhood trauma(P<0.05).In study group,the plasma lncRNA 51A level was positively correlated with EA,SA and PA scores(P<0.05)and negatively correlated with the correct recognition rates of sadness and fear(P<0.05).High Hamilton Depression Scale(HAMD)score,high Young Mania Rating Scale(YRMS)score,high lncRNA 51A level and childhood trauma were risk factors for bipolar disorder in remission(P<0.05).Conclusion The expression level of lncRNA 51A in patients with remission bipolar disorder is significantly increased,which is related to childhood trauma scores such as EA,SA and PA,as well as the evaluation of emotional cognitive function such as the correct recognition rates of
作者
刘光伟
邓巧恩
赵栋
綦航
赵俊霞
LIU Guangwei;DENG Qiaoen;ZHAO Dong(The Eighth Hospital of Shijiazhuang, Shijiazhuang 050000, China)
出处
《精神医学杂志》
2021年第1期20-24,共5页
Journal of Psychiatry
基金
河北省医学科学研究重点课题(编号:20181082)。
