摘要
目的探讨β-连环蛋白(β-catenin)和CD146在胃癌组织中的表达情况及临床意义。方法选取108例胃癌患者(胃癌组)组织标本,再选取40例因胃部疾病就诊的非胃癌患者(对照组)胃组织标本,采用免疫组织化学法检测两组患者β-catenin、CD146的表达情况,并分析其与胃癌之间的关系。结果胃癌组组织中β-catenin、CD146阳性表达率均明显高于对照组,差异均有统计学意义(P﹤0.01)。Spearman相关性分析显示,β-catenin、CD146阳性表达与胃癌的发生均呈正相关(r=0.568、0.587,P﹤0.01)。Logistic多因素回归分析显示,低分化,TNM分期为Ⅲ、Ⅳ期,淋巴结转移均是胃癌患者胃癌组织中β-catenin阳性表达的危险因素(P﹤0.05);TNM分期为Ⅲ、Ⅳ期和淋巴结转移是胃癌患者胃癌组织中CD146阳性表达的危险因素(P﹤0.05)。结论β-catenin、CD146阳性表达与胃癌的发生密切相关,可作为判断胃癌发生、发展和治疗的靶点。
Objective To investigate the expression of β-catenin and CD 146 in gastric cancer tissue and its clinical significance.Method A total of 108 gastic cancer patients(gastric cancer group) and their tissue samples and 40 gastric tissue samples of non-gastric cancer patients(control group) were selected and collected.The expression of β-catenin and CD 146 were detected by immunohistochemistry assay,and its relationship with gastric cancer was also analyzed.Result The positive expression rate of β-catenin and CD 146 in the gastric cancer group were significantly higher than those in the control group(P<0.01).Spearman correlation analysis indicated that the positive expression of β-catenin and CD 146 were positively correlated with the occurrence of gastric cancer(r=0.568,0.587,P<0.01).Logistic multivariate regression analysis showed that poorly differentiated,Ⅲ and Ⅳ TNM stages,and lymph node metastasis were risk factors for the positive expression of β-catenin in gastric cancer tissues(P<0.05);TNM stages were Ⅲ and Ⅳ,and lymph nodes metastasis were either risk factors for the positive expression of CD 146 in cancer tissues from patients with gastric cancer(P<0.05).Conclusion The positive expression of β-catenin and CD 146 are closely related to the initial of gastric cancer,which could be used as targets for predicting the occurrence,development,and treatment of gastric cancer.
作者
谢军
周磊
XIE Jun;ZHOU Lei(Department of Gastroenterology,Jing’an Branch,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China)
出处
《癌症进展》
2021年第6期575-577,614,共4页
Oncology Progress
基金
2019年上海市医学重点专科建设计划项目(ZK2019B24)。
