摘要
CD146是一种新发现的Ca2+非依赖性细胞黏附分子,属于免疫球蛋白超家族成员。CD146介导细胞与细胞间或细胞与细胞外基质之间的相互作用,促进内皮细胞的黏附与增殖,参与肿瘤血管新生和转移。CD146在许多恶性肿瘤组织中高表达,促进肿瘤细胞迁徙和转移,提示CD146可能在肿瘤侵袭和转移中起重要作用,可作为肿瘤患者预后判断的参考指标。
CD146 is a novel Ca2＋-independent cell adhesion molecule that belongs to the immunoglobulin superfamily.CD146 mediates cell-to-cell or cell-to-extracellular matrix interactions,which promotes the adhesion and proliferation of endothelial cells,and participates in angiogenesis and metastasis of tumor cells.CD146 was observed overexpressing in many malignant tumor tissues,which promoted the migration and metastasis of tumor cells.That indicated CD146 may play an important role in tumor invasion and metastasis,and it may be a new candidate target for tumor prognosis prediction.
出处
《医学研究生学报》
CAS
2010年第11期1222-1226,共5页
Journal of Medical Postgraduates
基金
南京军区南京总医院科研基金(2010Q009)
