摘要
拓扑异构酶(topoisomerase,topo)是解决DNA复制、转录等过程中出现拓扑问题的关键酶,是抗肿瘤药物作用的重要靶点之一。天然产物是topo抑制剂的重要来源,从天然产物中发现开发topo抑制剂是抗肿瘤药物研究的热点。以天然产物结构类型,分类综述了天然存在的具有topo抑制活性的天然产物及以它们为基础改造获得的衍生物,以期为抗肿瘤天然topo抑制剂的研发提供参考。
Topoisomerase(topo)plays the vital role in solving all of the topological problems of DNA in replication,transcription and other cellular transactions,which is one of the important targets of antitumor drugs.Natural products are an important source of development of topo inhibitors.Exploring topo inhibitors from natural products is one of the hot spots in the development of antitumor drugs.In this paper,the natural topo inhibitors and many derivatives based on natural products are reviewed,in order to provide reference for the development of antineoplastic topo inhibitors.
作者
戴一
宋祖荣
DAI Yi;SONG Zu-rong(College of Pharmacy,Anhui Xinhua University,Hefei 230088,China;Department of Chemistry,University of Science and Technology of China,Hefei 230026,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第6期1785-1798,共14页
Chinese Traditional and Herbal Drugs
基金
安徽省教育厅自然科学研究重点项目(KJ2019A0873)。
关键词
抗肿瘤
天然产物
拓扑异构酶抑制剂
结构改造
萜类
生物碱类
酚类
醌类
antitumor
natural products
topoisomerase inhibitors
structure modification
terpene
alkaloids
phenols
quinones
