摘要
Marine microorganisms have proven to be a rich source of natural products with unique structures and novel activities,due to their special living conditions.Macrolactins(MLNs),mostly produced by marine-derived microorganisms,are a group of 24-membered lactone natural products,which exhibit potent antibacterial,antifungal,antiviral,anticancer,antiinfammatory,anti-angiogenic and other activities.Their extensive biological activities make them potential compounds for drug development.MLNs are biosynthesized via a type I polyketide synthase(PKS)pathway with diferent tailoring steps,such as epoxidation,glycosylation and acylation.These modifcation steps provide opportunities to diversify their structures by combinatorial biosynthesis strategies.This review mainly focuses on the newly discovered MLNs in the past fve years,including their biological activities and relevant biosynthetic studies.
基金
This work was fnancially supported by the grants from the National Key R&D Program of China(2019YFC0312501)
the National Natural Science Foundation of China(U1706206,31570032).