摘要
目的:探讨多孔腹腔镜手术治疗卵巢癌的效果及对血清肝素结合性表皮生长因子(heparin-binding epidermal growth factor,HB-EGF)水平的影响。方法:选取2018年1月-2020年2月本院收治的70例卵巢癌患者,按照随机数字表法将其分为两组,各35例。对照组给予开腹手术治疗,观察组给予多孔腹腔镜手术治疗。比较两组术中与术后指标、外周血T淋巴细胞水平、血清HB-EGF水平、术后并发症发生情况。结果:观察组术中出血量、住院时间均少于对照组(P<0.05);两组手术时间、淋巴结清扫数目比较,差异均无统计学意义(P>0.05)。术后1周,两组外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较术前降低,CD8^(+)水平较术前提升,且观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P<0.05)。术后1周,两组血清HB-EGF水平均较术前降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:多孔腹腔镜手术对卵巢癌患者创伤小、术后并发症少、康复快,且对免疫功能影响小,血清HB-EGF水平下降更明显,肿瘤负荷减少更显著。
Objective:To investigate the effect of porous laparoscopic surgery on ovarian cancer and its influence on serum heparin-binding epidermal growth factor(HB-EGF).Method:A total of 70 ovarian cancer patients admitted to our hospital from January 2018 to February 2020 were selected,they were divided into two groups according to the random number table method,35 cases in each group.The control group was treated with laparotomy,the observation group was treated with porous laparoscopic surgery.Intraoperative and postoperative indexes,T lymphocyte level in peripheral blood,serum HB-EGF level and postoperative complications were compared between two groups.Result:The amount of intraoperative blood loss and length of hospital stay in the observation group were all lower than those in the control group(P<0.05);there were no significant differences in operation time and number of lymph node dissection between two groups(P>0.05).One week after operation,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in peripheral blood of two groups were decreased compared with those of before operation,the level of CD8^(+)was increased compared with that of before operation,moreover,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were all higher than those in the control group,the level of CD8^(+)was lower than that in the control group,with statistically significant differences(P<0.05).One week after operation,the serum HB-EGF level in both groups was lower than that before operation,the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).The incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Porous laparoscopic surgery has less trauma,fewer postoperative complications,faster recovery,less impact on immune function,more obvious decrease in serum HB-EGF level and more significant decrease in tumor burden in ovarian cancer patients.
作者
陈少辰
CHEN Shaochen(Jiamusi Central Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2021年第3期35-38,共4页
Medical Innovation of China
关键词
多孔腹腔镜
卵巢癌
T淋巴细胞
HB-EGF
Porous laparoscopy
Ovarian cancer
T lymphocyte
Heparin-binding epidermal growth factor
