摘要
目的分析大量输血对创伤患者炎症因子、凝血功能的影响。方法选取2018年1月至2019年12月在我院接受治疗的88例创伤患者作为研究对象,根据输血量将其分为观察组(48例,大量输血)和对照组(40例,少量输血)。比较两组患者输血前及输血后1、5 d的炎症因子水平及凝血功能指标。结果输血后1 d,观察组的CRP、IL-6、TNF-α水平均明显高于输血前及对照组(P<0.05);输血后5 d,两组的各项血清炎症因子水平比较,差异无统计学意义(P>0.05)。输血后1 d,观察组PT、APTT及TT明显长于输血前及对照组,FIB水平明显低于输血前及对照组(P<0.05);输血后5 d,两组的各项凝血功能指标比较,差异无统计学意义(P>0.05)。结论大量输血能够挽救创伤患者的生命安全,但会对患者炎症因子水平、凝血功能产生一定的影响,治疗期间应予以高度关注。
Objective To analyze the effects of massive blood transfusion on inflammatory factors and coagulation function in trauma patients.Methods A total of 88 trauma patients who received treatment in our hospital from January 2018 to December 2019 were selected as the research objects,and the patients were divided into observation group(48 cases,massive blood transfusion)and control group(40 cases,small amount of blood transfusion)according to the amount of blood transfusion.The inflammatory factors level and coagulation function of the two groups were compared before and 1,5 d after blood transfusion.Results On the first day after blood transfusion,CRP,IL-6 and TNF-αlevels in the observation group were significantly higher than those before blood transfusion and in the control group(P<0.05);on the 5th day after blood transfusion,there were no significant differences in the levels of serum inflammatory factors between the two groups(P>0.05).On the first day after blood transfusion,PT,APTT and TT in the observation group were significantly longer than those before blood transfusion and in the control group,FIB level was significantly lower than that before blood transfusion and in the control group(P<0.05);on the 5th day after blood transfusion,there were no significant differences in coagulation function indexes between the two groups(P>0.05).Conclusion Massive blood transfusion can save the life safety of trauma patients,but it has a certain impact on the level of inflammatory factors and coagulation function,which should be paid close attention during treatment.
作者
孙立涛
SUN Litao(the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,China)
出处
《临床医学研究与实践》
2021年第10期91-93,共3页
Clinical Research and Practice
关键词
大量输血
创伤
炎症因子
凝血功能
massive blood transfusion
trauma
inflammatory factor
coagulation function
