摘要
目的研究2型糖尿病患者采用达格列净进行治疗的临床效果,和对血尿电解质以及叶酸水平所产生的影响。方法选择2017年12月—2019年12月在该院接受药物治疗的2型糖尿病患者88例,通过随机分组的方式分成对照组和治疗组,每组44例。对照组采用二甲双胍进行治疗;治疗组采用二甲双胍联合达格列净进行治疗。对比两组药物治疗总有效率、药物治疗前后血电解质、尿电解质、尿酸、血糖水平、血糖水平恢复正常时间和住院总时间、药物不良反应及糖尿病并发症情况。结果治疗组患者药物治疗总有效率90.9%,高于对照组的70.5%,差异有统计学意义(χ^(2)=5.906,P<0.05);药物治疗前后血电解质、尿电解质水平的变化幅度小于对照组,差异有统计学意义(P<0.05);用药前后尿酸和血糖水平的改善幅度大于对照组,差异有统计学意义(P<0.05);血糖水平恢复正常时间和住院总时间短于对照组,差异有统计学意义(P<0.05);药物不良反应1例及糖尿病并发症1例均少于对照组的9例和8例,差异有统计学意义(χ^(2)=7.221、6.065,P<0.05)。结论2型糖尿病患者采用达格列净进行治疗,可以大幅度改善血糖和尿酸水平,对血、尿电解质所产生的影响较小,能够明显缩短治疗时间,减少药物相关不良反应及糖尿病并发症的发生,使治疗效果及患者满意度得到显著提升。
Objective To study the clinical effect of dapagliflozin treatment in patients with type 2 diabetes,and the effect on blood and urine electrolytes and folic acid levels.Methods A total of 88 patients with type 2 diabetes who received drug treatment in the hospital from December 2017 to December 2019 were selected and randomly divided into a control group and a treatment group,with an average of 44 cases in each group.The control group was treated with metformin;the treatment group was treated with metformin combined with dapagliflozin.The total effective rate of drug treatment,blood electrolytes,urine electrolytes,uric acid,blood glucose levels before and after drug treatment,the time for blood glucose levels to return to normal and the total length of hospital stay,adverse drug reactions and diabetes complications were compared between the two groups.Results The total effective rate of drug treatment in the treatment group was 90.9%,which was higher than 70.5%in the control group,the difference was statistically significant(χ^(2)=5.906,P<0.05);the changes in blood and urine electrolyte levels before and after drug treatment were smaller than those in the control group,the difference was statistically significant(P<0.05);the improvement range of uric acid and blood glucose levels before and after medication is greater than that of the control group,the difference was statistically significant(P<0.05);the blood glucose level returning to normal time and total hospital stay were shorter than those of the control group,the difference was statistically significant(P<0.05);1 case of adverse drug reaction and 1 case of diabetic complications were less than 9 cases and 8 cases in the control group,the difference was statistically significant(χ^(2)=7.221,6.065,P<0.05).Conclusion The treatment of type 2 diabetic patients with dapagliflozin can greatly improve blood sugar and uric acid levels,and has little effect on blood and urine electrolytes.It can significantly shorten the treatment time and reduce drug-related adver
作者
李芳芳
苏靖
LI Fang-fang;SU Jing(Department of Geriatrics,Seventh People's Hospital of Jinan City,Jinan,Shandong Province,250101 China;Department of Obstetrics and Gynecology,Seventh People's Hospital of Jinan City,Jinan,Shandong Province,250101 China)
出处
《世界复合医学》
2021年第2期195-198,共4页
World Journal of Complex Medicine
关键词
2型糖尿病
达格列净
血电解质
尿电解质
尿酸
血糖
并发症
不良反应
Type 2 diabetes
Dapagliflozin
Blood electrolytes
Urine electrolytes
Uric acid
Blood glucose
Complications
Adverse reactions
