摘要
目的:探讨厄贝沙坦联合小剂量利尿剂对老年单纯收缩期高血压患者的疗效及血清学指标影响。方法:收集2013年1月~2016年1月在本院接受治疗的老年单纯收缩期高血压患者110例,按照随机数表法分为观察组55例,对照组55例。观察组接受厄贝沙坦联合小剂量氢氯噻嗪治疗,对照组接受氨氯地平联合小剂量氢氯噻嗪治疗,治疗4周后,测定两组无创血压及血压变异性,检测血清内皮功能指标、炎症因子及氧化应激指标含量。结果:治疗4周后,观察组收缩压(SBP)、24 h平均收缩压(24h SBP)、24 h收缩压标准差(24 h SSD)水平显著低于对照组(P<0.05);血清内皮功能指标内皮素-1(EF-1)含量低于对照组,一氧化氮(NO)、内皮型NO合成酶(e NOS)含量高于对照组(P<0.05);血清炎症因子超敏C反应蛋白(hs-CRP)、白介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)含量低于对照组(P<0.05);血清氧化指标丙二醛(MDA)含量低于对照组,抗氧化指标总抗氧化能力(TAS)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)含量高于对照组(P<0.05)。结论:厄贝沙坦联合小剂量氢氯噻嗪可有效降低老年单纯收缩期高血压患者的收缩压并减小血压变异性,同时优化全身炎症、氧化应激等状态。
Objective： To study the influence of irbesartan combined with low dose urokinase on treatment effect and serologic indexes in elderlyisolated systolic hypertension patients. Methods： One hundred and ten cases of elderlyisolated systolic hypertension patients in our hospital during January 2013-January 2016 were randomly divided into observation group with 55 cases and control group with 55 cases. Patients in observation group received irbesartan combined with low dose hydrochlorothiazide treatment and those in control group received amlodipine combined with low dose hydrochlorothiazide treatment,each lasted for four weeks. After four weeks treatment,Non invasive blood pressure and blood pressure variability indexes were measured,serum endothelial function,inflammatory factors and oxidative stress indexs were measured. Results： After four weeks treatment,patients systolic blood pressure（ SBP）,24 h mean systolic blood pressure（ 24 hS BP）,24 h systolic blood pressure standard deviation（ 24 hS SD） were significantly lower in observation group than in control group（ P〈0. 05）; serum endothelial function index EF-1 was lower in observation group than in control group,NO and eN OS were higher in observation group than in control group（ P〈0. 05）; serum hs-CRP,IL-1β,IL-6,IL-8,TNF-α contents were lower in observation group than in control group（ P〈0. 05）; serum oxidation indexssuch as MDA was lower in observation group than in control group,antioxidant indexs such as TAS,SOD,GSH were higher in observation group than in control group（ P〈0. 05）. Conclusions： Irbesartan combined with low dose hydrochlorothiazide can effectively reduce systolic hypertension and blood pressure variability in elderlyisolated systolic hypertension patients,while optimizing the systemic inflammation and oxidative stress status.
出处
《海南医学院学报》
CAS
2017年第1期30-33,共4页
Journal of Hainan Medical University
基金
国家自然科学基金项目(2016D01C245)~~
