摘要
目的:应用统计学方法和关联规则分析痛风性关节炎(GA)患者脂代谢的变化及其与尿酸、各炎症、免疫指标的相关性以及与所用中药的关联。方法:整理安徽中医药大学第一附属医院风湿免疫科2012年5月-2018年12月GA住院患者病例资料781例,采用SPSS 22.0对其实验室指标总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白-A1(ApoA1)、载脂蛋白-B(ApoB)与尿酸(UA)、炎症指标C反应蛋白(CPR)、α1-酸性糖蛋白(α1-AGP)、免疫指标免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)进行相关性分析,通过SPSS Clementine12.0软件Aprior模块分析中药与脂代谢相关指标的相关性,并对其所使用的中药进行频数统计。结果:781例GA患者TG上升342例(44%),HDL-C下降343例(44%),ApoA1下降516例(66%)。相关性分析示:TC与C3、C4、UA呈显著正相关,与IgA、IgG、IgM、α1-AGP呈显著负相关;TG与UA呈显著正相关,与C4、CPR、α1-AGP呈显著负相关;LDL-C与C3、C4呈显著正相关,与IgA、IgG呈显著负相关;HDL-C与UA呈显著负相关;ApoA1与IgM呈显著正相关,与IgA、IgG、CPR、α1-AGP呈显著负相关;ApoB与UA、C3、C4、α1-AGP呈显著正相关,与IgG呈显著负相关(P<0.05或P<0.01)。中药使用频次分析示:使用频次最高的前4类药物为健脾化湿药、清热解毒药、活血化瘀药、祛风湿药。设定最小置信度为70%,最小支持度为20%。郁金关联于HDL-C上升,山药关联于ApoA1上升,药对威灵仙-郁金关联于HDL-C上升,药对山药-泽泻关联于ApoA1上升。结论:GA患者存在脂代谢紊乱,主要表现为TG上升、HDL-C和ApoA1下降,且与UA、免疫、炎症等指标相关。中医药干预与指标的改善有相关性,使用频次最高的前4类药物为健脾化湿药、清热解毒药、活血化瘀药、祛风湿药。其中以单味药物郁金、药对威灵仙-郁金与HDL-C上升显著�
Objective:To analyze the changes of lipid metabolism in patients with Cout Arthritis(GA)and its correlation with uric acid,inflammation,immune indexes and Traditional Chinese Medicine.Methods:Collected the case data of 781 inpatients in the department of rheumatology and immunity of the First Affiliated ospital of Anhui University of Chinese Medicine from May 2012 to December 2018.Its laboratory indexes in SPSS 22.0 total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB)and uric acid(UA),inflammation index C reactive protein(CPR),and alpha 1-acid glycoprotein(α1-AGP),immune index immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),complement 3(C3)and 4(C4)complement for correlation analysis.The correlation between TCM and lipid metabolism was analyzed with SPSS Clementine12.0 software Aprior module.The frequency statistics of Traditional Chinese Medicine were also made.Results:TG increased in 781 GA patients in 342(44%).Hdl-c decreased in 343 cases(44%).ApoA1 decreased in 516 cases(66%).Correlation analysis showed that TC was positively correlated with C3,C4 and UA,and negatively correlated with IgA,IgG,IgM and alpha 1-agp.TG was positively correlated with UA and negatively correlated with C4,CPR and alpha 1-agp.Ldl-c was significantly positively correlated with C3,C4 and IgA,and negatively correlated with IgG.Hdl-c was negatively correlated with UA.There was a significant positive correlation between ApoA1 and IgM,and a significant negative correlation with IgA,IgG,CPR and alpha 1-agp.ApoB was positively correlated with UA,C3,C4 and alpha 1-agp,and negatively correlated with IgG(P<0.05 or P<0.01).The frequency analysis of Traditional Chinese Medicine showed that the top four drugs with the highest frequency of use were Jianpi Huashi,Qingrejiedu,Huoxue Huayu and Rheumatoid.Set the minimum confidence to 70%and the minimum support to 20%.Yujin was associated with an increase in HDL-C
作者
韩馨悦
刘健
孙艳秋
张国磊
忻凌
贺明玉
HAN Xin-yue;LIU Jian;SUN Yan-qiu;ZHANG Guo-lei;XIN Ling;HE Ming-yu(Anhui University of Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China)
出处
《江西中医药大学学报》
2021年第2期33-37,共5页
Journal of Jiangxi University of Chinese Medicine
基金
科技部国家重点研发计划中医药现代化研究重点专项(2018YFC1705200,2018YFC1705204)
安徽省重点研究和开发计划对外科技合作项目(201904b11020011)
安徽省科技重大专项计划(17030801009)
安徽省名中医刘健工作室建设项目(中医药发展秘[2018]11号)
安徽省教育厅高校自然科学研究重点项目(KJ2018A0279)。
关键词
痛风性关节炎
脂代谢
尿酸
炎症指标
免疫指标
中医药干预
数据挖掘
Gouty Arthritis
Lipid Metabolism
Uric Acid
Inflammation Indicators
Immune Indicators
Chinese Medicine Intervention
Data Mining
