摘要
目的分析银离子敷料与湿疗伤口敷料治疗糖尿病足感染对患者纤维蛋白原(FIB)、超敏C-反应蛋白(hs-CRP)以及降钙素原(PCT)水平和溃疡程度的影响。方法以2018年8月-2020年3月于河北医科大学第二医院内分泌科接受治疗的84例糖尿病足感染患者为研究对象,通过随机数字表法分为研究组(n=42)和对照组(n=42)。对照组创面覆盖湿疗伤口敷料,研究组创面覆盖银离子敷料,试验终点为患者糖尿病足感染痊愈或治疗30 d后。比较两组治疗后临床指标、治疗30 d后疗效、治疗前及治疗30 d后溃疡程度、血清炎症因子水平。结果研究组患者清创时间、肉芽组织生长时间以及上皮形成时间短于对照组(P<0.05)。治疗30 d后,研究组治愈率高于对照组,有效率低于对照组(26.19%vs 7.14%,30.95%vs 64.29%,P<0.05)。治疗30 d后,研究组患者2级溃疡比例高于对照组、3级溃疡比例低于对照组(88.10%vs 59.52%,9.52%vs 33.33%,P<0.05)。与治疗前比较,治疗30 d后,两组血清FIB、PCT、hs-CRP水平均降低,研究组低于对照组(P<0.05)。结论相较湿疗伤口敷料,银离子敷料可降低糖尿病足感染患者FIB、PCT、hs-CRP水平,控制炎症反应,同时降低糖尿病足溃疡严重程度,促进创面修复。
OBJECTIVE To observe the effects of silver ion dressing and wet wound healing dressing on levels of fibrinogen(FIB),high-sensitivity c-reactive protein(hs-CRP)and procalcitonin(PCT)as well as degree of ulcer of the patients with diabetic foot infection.METHODS A total of 84 patients with diabetic foot infection who were treated in department of endocrinology of the Second Hospital of Hebei Medical University from Aug 2018 to Mar 2020 were enrolled in the study and randomly divided into the study group with 42 cases and the control group with 42 cases.The control group was treated with wet wound healing dressing for coverage of wound,while the study group was treated with silver ion dressing for coverage of wound,the terminal point of the test was the cure of diabetic foot infection or 30 days after the treatment.The clinical indexes after the treatment,curative effect after the treatment for 30 days,degree of ulcer and levels of serum inflammatory factors before the treatment and after the treatment for 30 days were observed and compared between the two groups.RESULTS The time of debridement,growth time of granulation tissue and time of epithelial formation were significantly shorter in the study group than in the control group(P<0.05).The cure rate of the study group was significantly higher than that of the control group after the treatment for 30 days,and the effective rate of the study group was significantly lower than that of the control group(26.19%vs 7.14%,30.95%vs 64.29%,P<0.05).The proportion of the patients with grade 2 ulcer was significantly higher in the study group than in the control group after the treatment for 30 days,while the proportion of the patients with grade 3 ulcer was significantly lower in the study group than in the control group(88.10%vs 59.52%,9.52%vs 33.33%,P<0.05).The levels of serum FIB,PCT and hs-CRP of the two groups significantly were lower after the treatment for 30 days than before the treatment,and the levels of above indexes of the study group were significantly lower tha
作者
秦玲
郝志华
於丽红
杨俊花
张力辉
QIN Ling;HAO Zhi-hua;YU Li-hong;YANG Jun-hua;ZHANG Li-hui(The Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第5期721-724,共4页
Chinese Journal of Nosocomiology
基金
河北省医学科学研究重点课题基金资助项目(20150248)。
关键词
糖尿病足感染
银离子敷料
湿疗伤口敷料
纤维蛋白原
超敏C-反应蛋白
降钙素原
溃疡
Diabetic foot infection
Silver ion dressing
Wet wound healing dressing
Fibrinogen
High-sensitivity C-reactive protein
Procalcitonin
Ulcer
